熊本大学大学院生命科学研究部 皮膚病態治療再建学講座
Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University
研究業績
研究内容
皮膚病態治療再建学講座では、伝統ある悪性腫瘍の研究に加え、膠原病を中心に、多彩な研究を精力的に行っています。
◆悪性黒色腫
遺伝子改変iPS細胞由来マクロファージによる免疫療法の開発
新規治療標的の同定
免疫療法におけるバイオマーカーの開発
◆膠原病・自己免疫疾患
膠原病の臨床研究
強皮症皮膚由来線維芽細胞を用いた基礎研究
皮膚筋炎の皮膚特異的分子の研究
microRNAの研究
◆その他皮膚悪性腫瘍
マウス化学発癌モデルを用いた多段階発癌機構の解明
皮膚筋炎、有棘細胞癌における発癌の研究
◆創傷治癒・血管新生
創傷治癒のメカニズムの研究
血管腫モデルなどを用いた血管新生・リンパ管新生の研究
毛髪再生治療に向けた毛の再生メカニズムの解明
◆尋常性乾癬
新規血清マーカーの開発
業績
※和文論文は多数にのぼるため、割愛します 。
2014年
2015年
2016年
2017年
2018年
2019年
2020年
2014年論文目録
1) Ikeda I, Ohno T, Ohno H, Miyazaki Y, Nishimoto K, Fukushima S, Makino T, Ihn H.
Case of Fusarium paronychia successfully treated with occlusive dressing of
antifungal cream.
J Dermatol, 41:340-342, 2014.
2) Inoue Y, Menzies SW, Fukushima S, Nishi-Kogushi H, Miyashita A, Masuguchi S, Muchemwa F, Kageshita T, Ihn H.
Dots/ globules on dermoscopy in nail-apparatus melanoma.
Int J Dermatol, 53: 88-92, 2014.
3) Jinnin M.
Various applications of microRNAs in skin diseases.
J Dermatol Sci, 74:3-8, 2014.
4) Fukushima S, Morita E, Tanioka M, Miyachi Y, Murakami Y, Matsunaka H, Ihn H.
Clinical evaluation of moisturizers with physiological analysis of stratum corneum
TARC and TSLP.
J Cosmetics, Dermatological Sciences and Applications, 4: 37-43, 2014.
5) Fukushima S, Masuguchi S, Igata T, Harada M, Aoi J, Miyashita A, Nakahara S,
Inoue Y, Jinnin M, Shiraishi S, Yamashita Y, Ishihara T, Ihn H.
Evaluation of sentinel node biopsy for cutaneous squamous cell carcinoma.
J Dermatol, 41: 539-541, 2014.
6) Makino T, Jinnin M, Etoh M, Yamane K, Kajihara I, Makino K, Ichihara A, Igata T,
Sakai K, Fukushima S, Ihn H.
Down-regulation of microRNA-196a in the sera and involved skin of localized scleroderma patients.
Eur J Dermatol, 24: 470-476, 2014.
7) Ichihara A, Wang Z, Jinnin M, Izono Y, Shimozono N, Yamane K, Fujisawa A, Moriya C, Fukushima S, Inoue Y, Ihn H.
Up-regulation of miR-18a contributes to the epidermal necrolysis in severe drug eruptions.
J Allergy Clin Immunol, 133: 1065-1074, 2014.
8) Ichihara A, Jinnin M, Fukushima S, Inoue Y, Ihn H.
Case of disseminated cutaneous Mycobacterium chelonae infection mimicking cutaneous vasculitis.
J Dermatol, 41: 414-417, 2014.
9) Kajihara I, Jinnin M, Yamada S, Ichihara A, Makino T, Igata T, Masuguchi S, Fukushima S, Ihn H.
Successful treatment of skin fistulas in systemic sclerosis patients with the combination of topical negative pressure therapy and split-thickness skin grafting. Mod Rheumatol, 24: 374-376, 2014.
10) Kajihara I, Jinnin M, Harada M, Makino K, Honda N, Makino T, Igata T,
Masuguchi S, Fukushima S, Ihn H.
miR-205 down-regulation promotes proliferation of dermatofibrosarcoma protuberans tumor cells by regulating LRP-1 and ERK phosphorylation.
Arch Dermatol Res, 306: 367-374, 2014.
11) Kajihara I, Makino K, Ichihara A, Fukushima S, Jinnin M, Hirooka S, Kojima K, Kourogi H, Ihn H.
Immunoglobulin G4-related disease in a psoriasis vulgaris patient treated with ustekinumab.
J Dermatol, 41: 670-671, 2014.
12) Niimori D, Kawano R, Niimori-Kita K, Ihn H, Ohta K.
Tsukushi is involved in the wound healing by regulating the expression of cytokines and growth factors.
J Cell Commun Signal, 8: 173-177, 2014.
13) Miyashita A, Fukushima S, Makino T, Yoshino Y, Yamashita J, Honda N, Aoi J Ichihara A, Jinnin M, Inoue Y, Ihn H.
The proportion of lymphocytic inflammation with CD123-positive cells in lupus erythematosus profundus predict a clinical response to treatment.
Acta Derm Venereol, 94: 563-567, 2014.
14) Aoi J, Endo M, Kadomatsu T, Miyata K, Ogata A, Horiguchi H, Odagiri H,
Matsuda T, Fukushima S, Jinnin M, Hirakawa S, Sawa T, Akaike T, Ihn H, Oike Y. Angiopoietin-like protein 2 accelerates carcinogenesis by activating chronic inflammation and oxidative stress.
Mol Cancer Res, 12: 239-249, 2014.
15) Aoi J, Nagamoto E, Masuguchi S, Fukushima S, Jinnin M, Ihn H.
A simple and effective reconstructive technique for repairing defects of the upper lip using a hatchet flap.
J Dermatol, 41: 1025-1026, 2014.
16) Aoi J, Masuguchi S, Fukushima S, Jinnin M, Ihn H.
Aesthethic reconstruction of defects in the lateral side wall of the nose using a local V-Y flap.
J Dermatol, 41: 1026-1028, 2014.
17) Makino K, Jinnin M, Aoi J, Kajihara I, Makino T, Fukushima S, Sakai K,
Nakayama K, Emoto N, Yanagisawa M, Ihn H.
Knockout of endothelial cell-derived endothelin-1 attenuates skin fibrosis but accelerate cutaneous wound healing.
PLoS One, 9: e97972, 2014.
18) Makino K, Jinnin M, Makino T, Kajihara I, Fukushima S, Inoue Y, Ihn H.
Serum levels of soluble carbonic anhydrase IX are decreased in patients with diffuse cutaneous systemic sclerosis compared to those with limited cutaneous systemic sclerosis.
BioScience Trends, 8: 144-148, 2014.
19) Kanemaru H, Jinnin M, Asao A, Ichihara A, Makino K, Kajihara I, Fujisawa A, Fukushima S, Ihn H.
A case of psoriasis accompanied by arthritis after delivery.
BioScience Trends, 8: 64-67, 2014.
20) Kanemaru H, Kajihara I, Yamanaka K, Igata T, Makino T, Masuguchi S,
Fukushima S, Jinnin M, Ihn H.
Platelet-rich plasma therapy is effective for the treatment of refractory skin ulcers in
patients with systemic sclerosis.
Mod Rheumatol, 16, Epub, 2014.
21) Kudo H, Jinnin M, Asano Y, Trojanowska M, Nakayama W, Inoue K, Honda N, Kajihara I, Makino K, Fukushima S, Ihn H.
Decreased IL-20 expression in scleroderma skin contributes to cutaneous fibrosis. Arthritis Rheumatol, 65: 1636-1647, 2014.
22) Kubo Y, Aoi J, Jono T, Makino T, Sakai K, Masuguchi S, Fukushima S, Jinnin,
Inoue Y, Ihn H.
A case of anaplastic large cell lymphoma of skeletal muscle.
J Dermatol, 41: 999-1002, 2014.
23) Kuriyama H, Jinnin M, Kanemaru H, Ichihara A, Fujisawa A, Moriya C,
Fukushima S, Ihn H.
Clincal significance of serum vascular endothelial-cadherin levels in inflammatory skin diseases.
Ann Dermatol, 26: 536-538, 2014.
24) Nagamoto E, Fujisawa A, Jinnin M, Koga H, Ishii N, Hashimoto T, Yoshino Y.
Case of pemphigoid vegetans positive with both BP180 and BP230 in enzyme-linked immunosorbent assays.
J Dermatol. 2014 Jul;41(7):667-8.
25) Noguchi H, Jinnin M, Miyata K, Hiruma M, Ihn H.
Clinical features of 80 cases with tinea faciei treated at a rural clinic in Japana
Drug Discov Ther 8: 245-248, 2014.
26) Asano Y, Ihn H, Jinnin M, Tamaki Z, Tamaki K, Sato S.
Serum levels of matrix metalloproteinase-13 in patients with eosinophilic fasciitis.
J Dermatol, 41: 746-748, 2014.
27) Hasegawa M, Asano Y, Endo H, Fujimoto M, Goto D, Ihn H, Inoue K, Ishikawa O, Kawaguchi Y, Kuwana M, Ogawa F, Takahashi H, Tanaka S, Sato S, Takehara K. Serum adhesion molecule levels as prognostic markers in patients with early systemic sclerosis: a multicenter, prospective, observational study.
PLoS One, 9: e88150, 2014.
28) Tamaki Z, Asano Y, Kubo M, Ihn H, Tada Y, Sugaya M, Kadono T, Sato S.
Effects of the immunosuppressant rapamycin on the expression of human 2(I) collagen and matrix metalloproteinase 1 genes in scleroderma dermal fibroblasts.
J Dermatol Sci, 74: 251-259, 2014.
29) Kobayashi D, Hirayama M, Komohara Y, Mizuguchi S, Wilson Morifuji M, Ihn H, Takeya M, Kuramochi A, Araki N.
Transcriptionally controlled tumor protein is a novel biologic target for neurofibromatosis type I (NF-1) -associated tumors.
J Biol Chem, 289: 26314-26326, 2014.
30) Sugaya M, Tokura Y, Hamada T, Tsuboi R, Moroi Y, Nakahara T, Amano M, Ishida S, Watanabe D, Tani M, Ihn H, Aoi J, Iwatsuki K.
Phase II study of i.v. interferon-γin Japanese patient s with mycosis fungoides. J Dermatol, 41: 50-56, 2014.
31) Koga Y, Jinnin M, Ichihara A, Fujisawa A, Moriya C, Sakai K, Fukushima S,
Inoue Y, Ihn H.
Analysis of expression pattern of serum microRNA levels in patients with psoriasis. J Dermatol Sci, 74: 170-171, 2014.
32) Kusumoto S, Kajihara I, Nagatomo E, Makino K, Ichihara A, Aoi J, Johno T,
Makino T, Fukushima S, Jinnin M, Ihn H. Increased CCL22 expression in psoriatic skin predicts a good response to infliximab therapy.
Br J Dermatol, 171: 1259-1261, 2014.
33) Okada Y, Jinnin M, Makino T, Kajihara I, Makino K, Honda N, Nakayama W,
Inoue K, Fukushima S, Ihn H.
MIRSNP rs2910164 of miR-146a is associated with the muscle involvement in polymyositis/ dermatomyositis.
Int J Dermatol, 53: 300-304, 2014.
34) Ohyoshi Y, Makino T, Jinnin M, Nakayama W, Fukushima S, Inoue Y, Ihn H.
Serum levels of leptin receptor in patients with systemic sclerosis.
Intractable Rare Dis Res, 2: 55-58, 2014.
35) Sakoguchi A, Nakayama W, Jinnin M, Wang Z, Yamane K, Aoi J, Makino K,
Kajihara I, Ichihara A, Makino T, Fukushima S, Sakai K, Inoue Y, Ihn H.
The expression profile of the toll-like receptor family in scleroderma dermal fibroblasts.
Clin Exp Rheumatol, 32: S4-S9, 2014.
36) Tsuru Y, Jinnin M, Ichihara A, Fujisawa A, Moriya C, Sakai K, Fukushima S, Ihn H. miR-424 levels in hair shaft are increased in psoriasis patients.
J Dermatol, 41: 382-385, 2014.
2015年論文目録
1) Miyashita A, Fukushima S, Nakahara S, Yamashita J, Tokuzumi A, Aoi J, Ichihara A, Kanemaru H, Jinnin M, Ihn H.
Investigation of FOXM1 as a potential new target for melanoma.
PLoS One, 10: e0144241, 2015.
2) Kajihara I, Kanemaru H, Miyake T, Aoi J, Masuguchi S, Fuksuhima S, Jinnin M, Inoue Y, Ihn H.
Combination chemotherapy with S-1 and docetaxel for cutaneous angiosarcoma resistant to paclitaxel.
Drug Discov Ther, 9: 75-77, 2015.
3) Kajihara I, Maeda S, Yamada S, Izumi K, Masuguchi S, Fukushima S, Jinnin M, Ihn H.
Biweekly gemcitabine therapy induces complete remmision in cutaneous angiosarcoma resistant to multiple anticancer drugs.
J Dermatol, 42: 1197-1198, 2015.
4) Kudo H, Wang Z, Jinnin M, Nakayama W, Inoue K, Honda N, Nakashima T, Kajihara I, Makino K, Makino T, Fukushima S, Ihn H.
EBI3 downregulation contributes to type I collagen overexpression in scleroderma skin.
J Immunol, 195: 3565-3573, 2015.
5) Sawamura S, Kajihara I, Ichihara A, Fukushima S, Jinnin M, Yamaguchi E, Kohrogi H, Ihn H.
Crizotinib-associated erythema multiforme in a lung cancer patient.
Drug Discov Ther, 9: 142-143, 2015.
6) Nakamura K, Nakatsuka N, Jinnin M, Makino T, Kajihara I, Makino K, Honda N, Inoue K, Fukushima S, Ihn H.
Serum concentrations of Flt-3 ligand in rheumatic diseases.
Biosci Trends, 9: 342-349, 2015.
7) Kanemaru H, Kajihara I, Yamanaka K, Igata T, Makino T, Masuguchi S, Fukushima S, Jinnin M, Ihn H.
Platelet-rich plasma therapy is effective for the treatment of refractory skin ulcers in patients with systemic sclerosis.
Mod Rheumatol, 25: 660-661, 2015.
8) Wang Z, Jinnin M, Kobayashi Y, Kudo H, Inoue K, Nakayama W, Honda H, Makino K, Kajihara I, Makino T, Fukushima S, Ihn H.
Mice overexpressing integrin av in fibroblasts exhibit dermal thinning of the skin.
J Dermatol Sci, 79: 268-278, 2015.
9) Shimozono N, Jinnin M, Masuzawa M, Masuzawa M, Wang Z, Hirano A, Tomizawa Y, Etoh-Kira T, Kajihara I, Harada M, Fukushima S, Ihn H.
NUP160-SLC43A3 is a novel recurrent fusion oncogene in angiosarcoma.
Cancer Res, 75: 4458-4465, 2015.
10) Noguchi H, Hiruma M, Inoue Y, Miyata K, Tanaka M, Ihn H.
Tinea nigra showing parallel ridge pattern on dermoscopy.
J Dermatol, 42: 518-520, 2015.
11) Inada T, Fukushima S, Murai M, Jinnin M, Miyashita A, Nakahara S, Yamashita J, Aoi J, Masuguchi S, Ihn H.
Hair shaft microRNA-221 levels as a new tumor marker of malignant melanoma.
J Dermatol, 42: 198-201, 2015.
12) Kumasasa MY, Yajima I, Iida M, Takahashi H, Inoue Y, Fukushima S, Ihn H, Takeda K, Naito Y, Yoshikawa T, Kato M.
Correlated expression levels of endothelin receptor B and Plexin C1 in melanoma. Am J Cancer Res, 5: 1117-1123, 2015.
13) Saito Y, Ohnishi K, Miyashita A, Nakahara S, Fujiwara Y, Horiad H, Motoshima T, Fukushima S, Jinnin M, Ihn H, Takeya M, Komohara Y,
Prognostic significance of CD169+ lymph node sinus macrophages in patients with malignant melanoma.
Cancer Immunol Res, 3: 1356-1363, 2015.
14) Sakaizawa K, Ashida A, Uchiyama A, Ito T, Fujisawa Y, Ogata D, Matsushita S, Fujii K, Fukushima S, Shibayama Y, Hatta N, Takenouchi T, Uehara J, Okuyama R, Yamazaki N, Uhara H.
Clinical characteristics associated with BRAF, NRAS and KIT mutations in Japanese melanoma patients.
J Dermatol Sci, 80: 33-7, 2015.
15) Sato A, Ichihara A, Jinnin M, Fukushima S, Ihn H.
Serum miR-124 up-regulation as a disease marker of toxic epidermal necrolysis.
Eur J Dermatol, 25: 457-462, 2015.
16) Soga M, Ishitsuka Y, Hamasaki M, Yoneda K, Furuya H, Matsuo M, Ihn H, Fusaki N, Nakamura K, Nakagata M, Endo F, Irie T, Era T.
HPGCD outperforms HPBCD as a potential treatment for Niemann-Pick diseadse type C during disease modeling with iPS cells.
Stem Cells, 34: 1075-1088, 2015.
17) Miyamoto Y, Watanabe M, Ishimoto T, Baba Y, Iwagami S, Sakamoto Y, Yoshida N, Masuguchi S, Ihn H, Baba H.
Fascia lata onlay patch for repairing infected incisional hernias.
Surg Today, 45:121-7124, 2015.
2016年論文目録
1) Nogami R.
Analysis of problems on applying ICD-10 coding rules to the medical history management of the Hansen’s disease patients/ex-patients.
The 19th International Leprosy Congress, 19-21, Srpt, 2016, Beijing.
2) Yoshino Y, Ohtsuka M, Kawaguchi M, Sakai K, Hashimoto A, Hayashi M, Madokoro N, Asano Y, Abe M, Ishii T, Isei T, Ito T, Inoue Y, Imafuku S, Irisawa R, Ohtsuka M, Ogawa F, Kadono T, Kawakami T, Kukino R, Kono T, Kodera M, Takahara M, Tanioka M, Nakanishi T, Nakamura Y, Hasegawa M, Fujimoto M, Fujiwara H, Maekawa T, Matsuo K, Yamasaki O, Le Pavoux A, Tachibana T, Ihn H.
The woud burn guidelines – 6: Guidelines for management of burns.
J Dermatol, 43: 989-1010, 2016.
3) Fukushima S, Motoyama K, Tanida Y, Higashi T, Ishitsuka Y, Kondo Y, Irie T, Tanaka T, Ihn H, Arima H.
Clinical evaluation of novel natural polysaccharides Sacran as a skincare material for atopic dermatitis patients.
J Cosmetics, Dermatological Sciences and Applications, 6: 9-18, 2016.
4) Makino T, Jinnin M.
Genetic and epigenetic abnormalities in systemic sclerosis.
J Dermatol, 43(1): 10-8, 2016.
5) Ichihara A, Jinnin M, Ihn H.
Treatment of psoriasis with ustekinumab improved skin tightening in systemic sclerosis.
Clin Exp Rheumatol, 106(4): 208-210, 2017.
6) Aoi J, Fukushima S, Jinnin M, Ihn H.
Fluorescence in situ hybridization for diagnosis of malignant melanoma using RREB1, MyB, Cep 6, and CCND1 probes in Japanese patients.
Dermatologica Sinica, in press.
7) Miyashita A, Fukushima S, Nakahara S, Kubo Y, Tokuzumi A, Yamashita J, Aoi J, Haruta M, Senju S, Nishimura Y, Jinnin M, Ihn H.
Immunotherapy against metastatic melanoma with human iPS cell-derived myeloid cell lines producing type I interferons.
Cancer Immunol Res, 4: 248-258, 2016.
8) Nakahara S, Fukushima S, Yamashita J, Kubo Y, Tokuzumi A, Miyashita A, Harada M, Nakamura K, Jinnin M, Ihn H.
AT-rich interaction domain-containing protein 3B is a new tumor marker for melanoma.
Acta Derma Venereol, 96: 112-114, 2017.
9) Inoue M, Jinnin M, Wang Z, Nakamura K, Inoue K, Ichihara A, Moriya C, Sakai K, Fukushima S, Ihn H.
microRNA level is raised in the hair shafts of patients with dermatomyositis in comparison with normal subjects and patients with scleroderma.
Int J Dermatol, 55: 786-790, 2016.
10) Egashira S, Jinnin M, Harada M, Masuguchi S, Fukushima S, Ihn H.
Exome sequence analysis of Kaposiform hemangioendothelioma: identification of putative driver mutations.
An Bras Dermatol, 91: 748-753, 2016
11) Egashira S, Kajihara I, Kanemaru H, Uemura-Kiyohara M, Yamada-Kanazawa S, Nakahara S, Nagamoto E, Fukushima S, Jinnin M, Inoue Y, Ihn H.
Achieved good response of S-1 and docetaxel combination chemotherapy in two patients with metastatic extramammary Paget’s disease.
J Dermatol, 44(5):103-4, 2017.
12) Tokuzumi A, Fukushima S, Miyashita A, Nakahara S, Kubo Y, Yamashita J, Harada M, Nakamura K, Kajihara I, Jinnin M, Ihn H.
Cell divison cycle-associated protein 1 as a new melanoma-associated antigen.
J Dermatol, 43: 1399-1405, 2016.
13) Nakayama W, Jinnin M, Tomizawa Y, Nakamura K, Kudo H, Inoue K, Makino K, Honda N, Kajihara I, Fukushima S, Ihn H.
Dysregulated Interleukin-23 signalling contributes to the increased collagen production in scleroderma fibroblasts via balancing microRNA expression.
Rheumatology, 56: 145-155, 2017.
14) Harada M, Jinnin M, Wang Z, Hirano A, Tomizawa Y, Kira T, Igata T, Masuguchi S, Fukushima S, Ihn H.
The expression of miR-124 increases in aged skin to cause cell senecense and it decreases in squamous cell carcinoma.
Biosci Trends, 10: 454-459, 2017.
15) Yamada-Kanazawa S, Kajihara I, Fukushima S, Jinnin M, Masuzawa M, Masuzawa M, Amoh Y, Hoshina D, Abe R, Ihn H.
Inhibition of HSP90 exerts anti-tumor effect on angiosarcoma: involvement of VEGF signaling pathway.
Br J Dermatol, 177(2): 456-69, 2017.
16) Yamada S, Jinnin M, Kajihara I, Nakashima T, Aoi J, Harada M, Igata T, Masuguchi S, Fukushima S, Ihn H.
Cytokine expression profiles in the sera of cutaneous squamous cell carcinoma patients.
Drug Discov Ther, 10: 172-176, 2016.
17) Yamada S, Kajihara I, Johno T, Fukushima S, Jinnin M, Masunaga A, Kohrogi H, Ihn H.
Symptomless Pulmonary Cryptococcosis in a Psoriatic Arthritis Patient during Infliximab Therapy.
Ann Dermatol, 28: 269-70, 2016.
18) Inoue Y, Hasegawa M, Maekawa T, Le Pavoux A, Asano Y, Abe M, Ishii T, Ito T, Isei T, Imafuku S, Irisawa R, Ohtsuka M, Ohtsuka M, Ogawa F, Kadono T, Kodera M, Kawakami T, Kawaguchi M, Kukino R, Kono T, Sakai K, Takahara M, Tanioka M, Nakanishi T, Nakamura Y, Hashimoto A, Hayashi M, Fujimoto M, Fujiwara H, Matsuo K, Madokoro N, Yamasaki O, Yoshino Y, Tachibana T, Ihn H.
The woud burn guidelines – 1: Wounds in general.
J Dermatol, 43: 357-375, 2016.
19) Noguchi H, Hiruma M, Miyashita A, Makino K, Miyata K, Ihn H.
A case of fingernail onychomycosis due to Aspergillus flavus.
Medical Mycol J, 57: E21-E25, 2016.
20) Noguchi H, Hiruma M, Maruo K, Jono M, Miyata K, Tanaka H, Tanabe K, Miyazaki Y, Ihn H.
Localized cutaneous cryptococcosis: Summary of reported cases in Japan.
Med Mycol J 57: E35-E39, 2016.
21) Noguchi H, Hiruma M, Matsumoto T, Kano R, Ihn H.
Ungual hyalohyphomycosis caused by Fusarium proliferatum in an immunocompetent patient.
J Dermatol, 44: 88-90, 2017.
22) Noguchi H, Hiruma M, Matsumoto T, Kano R, Ihn H.
Ungual aspergillosis successfully treated with topical efinaconazole.
J Dermatol, 44(7): 848-50, 2017.
23) Noguchi H, Hiruma M, Matsumoto T, Mitsui N, Sano A, Yaguchi T, Ihn H.
Subcutaneous cystic phaeohyphomycosis due to Pleurostomophora richardiae.
J Dermatol, 44(4): 62-63, 2017.
24) Noguchi H, Hiruma M, Matsumoto T, Takashima H, Ihn H.
Multiple subcutaneous Candida abcesses in an immunocompetent patient.
J Dermatol, 44(7): 176-77, 2017.
25) Noguchi H, Hiruma M, Matsumoto T, Kano R, Tanaka M, Yaguchi T, Sonoda K, Ihn H.
Fungal melanonychia: Ungual phaeohyphomycosis caused by Botryospheria dothidea.
Acta Derm Venereol, 97(6): 765-66, 2017.
26) Johno T, Egawa K, Jinnin M, Fukushima S, Masuguchi S, Inoue Y, Ihn H.
Clinical usefulness of immunostaining with CEA in distinction between malignant melanoma and Spitz nevus.
Invest Dermatol Venereol Res 2: 1-4, 2016.
27) Tanigawa H, Miyata H, Tian Z, Aoi J, Kadomatsu T, Fukushima S, Ogata A, Takeda N, Zhao J, Zhu S, Terada K, Endo M, Morinaga J, Sugizaki T, Sato M, Morioka MS, Manabe I, Mashimo Y, Hata A, Takemori Y, Yamamoto K, Murakami M, Araki K, Jinnin M, Ihn H, Oike Y.
Upregulation of ANGPTL6 in mouse keratinocytes enhances susceptibility to psoriasis.
Sci Rep, 6: 34690, 2016.
28) Nakamura K, Jinnin M, Harada M, Kudo H, Nakayama W, Inoue K, Ogata A, Kajihara I, Fukushima S, Ihn H.
Altered expression of CD63 and exomes in scleroderma dermal fibroblasts.
J Dermatol Sci, 84(1): 30-39, 2016.
29) Nakamura K, Jinnin M, Kudo H, Inoue K, Nakayama W, Honda N, Kajihara I, Masuguchi S, Fukushima S, Ihn H.
The role of PSMB9 up-regulation by interferon signature in the pathophysiology of cutaneous lesions of dermatomyositis and lupus erythematosus.
Br J Dermatol, 174: 1030-1041, 2016.
30) Nakamura K, Jinnin M, Fukushima S, Ihn H.
Identification of disease-specific molecules in the skin of dermatomyositis and lupus erythematosus by proteomics analysis using LC–MS/MS.
J Dermatol Sci, 84(1): 5, 2016.
31) Ide M, Jinnin M, Tomizawa Y, Wang Z, Kajihara I, Fukushima S, Hashizume Y, Asano Y, Ihn H.
Transforming growth factor β inhibitor Repsox down-regulates collagen expression of scleroderma dermal fibroblasts and prevents bleomycin-induced mice skin fibrosis.
Exp Dermatol, 26(11): 1139-1143.
32) Wang Z, Jinnin M, Nakamura K, Harada M, Kudo H, Nakayama W, Inoue K, Nakashima T, Honda N, Fukushima S, Ihn H.
Long non-coding RNA TSIX is up-regulated in scleroderma dermal fibroblasts and controls collagen mRNA stabilization.
Exp Dermatol, 25: 131-136, 2016.
33) Wang Z, Nakamura K, Jinnin M, Kudo H, Goto M, Era T, Kira T, Nakashima T, Fukushima S, Ihn H.
Establishment and gene expression analysis of disease-derived induced pluripotent stem cells of scleroderma.
J Dermatol Sci, 84(2): 186-196, 2016.
34) Wang Z, Jinnin M, Harada M, Kudo H, Inoue K, Nakayama W, Honda N, Makino K, Kajihara I, Fukushima S, Ihn H.
Diagnosis of nail psoriasis: evaluation of nail-derived microRNAs as potential novel biomarkers.
Eur J Dermatol, 27: 20-27, 2017.
35) Kimura T, Fukushima S, Miyashita A, Aoi J, Jinnin M, Kosaka T, Ando Y, Matsukawa M, Inoue H, Kiyotani K, Park J-H, Nakamura Y, Ihn H.
Myasthenic crisis and polymyositis induced by one dose of nivolumab.
Cancer Sci, 107(7): 1055-1058, 2016.
36) Sawamura S, Jinnin M, Shimbara M, Nakamura K, Kudo H, Inoue K, Nakayama W, Kajihara I, Fukushima S, Ihn H.
Serum levels of genomic DNA of α1(I) collagen are elevated in scleroderma patients.
J Dermatol, 44(8): 927-31, 2017.
37) Sawamura S, Kajihara I, Jinnin M, Honda Y, Ihn H.
Cutaneous spindle cell adenolipoma on the nose: A rare variant of lipoma.
J Dermatol, 44(7):156-7, 2017.
38) Sawamura S, Kajihara I, Makino K, Makino T, Fukushima S, Jinnin M, Oyama B, Hashimoto T, Ihn H.
Systemic lupus erythematosus associated with myasthenia gravis, pemphigus foliaceus and chronic thyroiditis after thymectomy.
Australas J Dermatol, 58(3): 120-122, 2017.
39) Nakashima S, Jinnin M, Masuzawa M, Amoh Y, Masuzawa M, Kanemaru H, Kajihara I, Igata T, Harada M, Masuguchi S, Fukushima S, Ihn H.
The role of miR 210 E2F3 and ephrin A3 in angiosarcoma cell proliferation.
Eur J Dermatol, 27(5): 464-471, 2017.
40) Maeda S, Kajihara I, Ogata A, Johno T, Jinnin M, Ihn H.
Bromoderma in a pituitary adenoma patient treated with bromocriptine.
J Dermatol, 44: 489-551, 2017.
41) Amagai M, Ikeda S, Hashimoto T, Mizuashi M, Fujisawa A, Ihn H, Matsuzaki Y, Ohtsuka M, Fujiwara H, Furuta J, Tago O, Yamagami J, Tanikawa A, Uhara H, Morita A, Nakanishi G, Tani M, Aoyama Y, Makino E, Muto M, Manabe M, Konno T, Murata S, Izaki S, Watanabe H, Yamaguchi Y, Matsukura S, Seishima M, Habe K, Yoshida Y, Kaneko S, Shindo H, Nakajima K, Kanekura T, Takahashi K, Kitajima Y, Hashimoto K.
A randomized double-blind trial of intranenous immunoglobulin for bullous pemphigoid.
J Dermatol Sci, 85: 77-84, 2017.
42) Isei T, Abe M, Nakanishi T, Matsuo K, Yamasaki O, Asano Y, Ishii T, Ito T, Inoue Y, Imafuku S, Irisawa R, Ohtsuka M, Ohtsuka M, Ogawa F, Kadono T, Kodera M, Kawakami T, Kawaguchi M, Kukino R, Kono T, Sakai K, Takahara M, Tanioka M, Nakamura Y, Hashimoto A, Hasegawa M, Hayashi M, Fujimoto M, Fujiwara H, Maekawa T, Madokoro N, Yoshino Y, Le Pavoux A, Tachibana T, Ihn H.
The woud burn guidelines – 3: Guidelines for the diagnosis and treatment for diabetic ulcer gangrene.
J Dermatol, 43: 591-619, 2016.
43) Izumiya Y, Jinnin M, Kimura Y, Wang Z, Onoue Y, Hanatani S, Araki S, Ihn H, Ogawa H.
Expression of Let-7 family microRNAs in skin correlates negatively with severity of pulmonary hypertension in patients with systemic scleroderma.
Int Cardiol Heart Vasc, 8: 98-102, 2015.
44) Ito T, Kukino R, Takahara M, Tanioka M, Nakamura Y, Asano Y, Abe M, Ishii T, Isei T, Inoue Y, Imafuku S, Irisawa R, Ohtsuka M, Ohtsuka M, Ogawa F, Kadono T,Kawakami T, Kawaguchi M, Kono T, Kodera M, Sakai K, Nakanishi T, Hashimoto A, Hasegawa M, Hayashi M, Fujimoto M, Fujiwara H, Maekawa T, Matsuo K, Madokoro N, Yamasaki O, Yoshino Y, Le Pavoux A, Tachibana T, Ihn H.
The woud burn guidelines – 5: Guidelines for management of lower leg ulcers/ varicose veins.
J Dermatol, 43: 853-868, 2016.
45) Ichigozaki Y, Fukushima S, Jinnin M, Miyashita A, Nakahara S, Tokuzumi A, Yamashita J, Kajihara I, Aoi J, Masuguchi S, Wang Z, Ihn H.
Serum long non-coding RNA, snoRNA host gene 5 level as a new tumor marker of malignant melanoma.
Exp Dermatol, 25(1): 67-69, 2016.
46) Inoue H, Park JH, Kiyotani K, Zewde M, Miyashita A, Jinnin M, Kiniwa Y, Okuyama R, Tanaka R, Fujisawa Y, Kato H, Morita A, Asai J, Katoh N, Yokota K, Akiyama M, Ihn H, Fukushima S, Nakamura Y.
Intratumoral expression levels of PD-L1, GZMA, and HLA-A along with oligoclonal T cell expansion associate with response to nivolmab in metastatic melanomas.
Oncoimmunology 5: e1204507, 2016.
47) Uchihara T, Imamura Y, Iwagami S, Kajihara I, Kanemaru H, Karashima R, Ida S, Ishimoto T, Baba Y, Sakamoto Y, Miyamoto Y, Yoshida N, Watanabe M, Iyama K, Ihn H, Baba H.
Small bowel perforation due to indistinguishable metastasis of angiosarcoma: case report and brief literature review.
Surg Case Rep 2: 42, 2016.
48) Umezaki N, Ishimoto T, Koba I, Nakaya T, Mawatari M, Kuramoto K, Izumi D, Sakamoto Y, Miyamoto Y, Yoshida N, Watanabe M, Inoue Y, Ihn H, Baba H.
Anorectal malignant melanoma with extensive intraepithelial extension: report of a case.
Int Canc Conf J, in press
49) Oka A, Asano Y, Hasegawa M, Fujimoto M, Ishikawa O, Kuwana M, Kawaguchi Y, Yamamoto T, Takahashi H, Goto D, Endo H, Jinnin M, Mano S, Hosomichi K, Mabuchi T, Beck S, Takehara K, Sato S, Ihn H.
RXRB is a novel susceptibility gene for anti-topoisomerase I antibody positive systemic sclerosis with MHC region.
J Invest Dermatol, 137: 1878-1886, 2017.
50) Kadono T, Furuta K, Nagai Y, Kanoh H, Sekine Y, Noda Y, Mizokami H, Kataoka H, Nakagawa H, Tanaka K, Daian T, Kurashige Y, Nakagami G, Makabe N, Sekine R, Takahasaki M, Yoshino K, Endo T, Hidaka M, Maeshige N, Kubota K, Motita T, Okuwa M, Miyajima M, Noguchi M, Kinoshita S, Sobue M, Matsui Y, Murooka Y, Ishida Y, Sugama J, Tachibana T, Inoue Y, Ihn H.
JSPU Guidelines for the prevention and management of pressure ulcers (4th Ed.).
Jpn J PU 18: 455-554, 2016.
51) Higashi-Kuwata N, Ogata-Aoki H, Hattori SI, Hayshi H, Danish M, Aoki M, Shiotsu C, Kuwamura T, Ihn H, Kobayashi H, Okada S, Mitsuya H.
Early phase dynamics of traceable mCherry fluorescent protein-carring HIV-1 infection in human peripheral blood mononuclear cells-transplanted NOD SCID Jak3 mice.
Antiviral Res, 144: 83-92, 2017.
52) Koga A, Kajihara I, Yamada S, Makino K, Ichihara A, Aoi J, Makino T, Fukushima S, Jinnin M, Ihn H.
Enhanced CCR9 expression levels in psoriatic skin are associated with poor clinical outcome to infliximab treatment.
J Dermatol, 43: 522-525, 2016.
53) Goto Y, Yajima I, Kumasaka M, Ohgami N, Tanaka A, Tsuzuki T, Inoue Y, Fukushima S, Ihn H, Kyoya M, Ohashi H, Kawakami T, Bennet DC, Kato M.
Transcription factor LSF (TFCP2) inhibits melanoma growth.
Oncotarget, 7: 2379-2390, 2016.
54) Sato Y, Kajihara I, Yamada-Kanazawa S, Jinnin M, Ihn H.
S100A7 expression levels in coordination with IL-8 indicate the clinical response to infliximab for psoriasis patients.
J Dermatol, 44(7), 838-9, 2017.
55) Saeki H, Nakagawa H, Nakajo K, Ishii T, Morisaki Y, Aoki T, Cameron GS, Osuntokun O, Akasaka T, Asano Y, Etoh T, Fujita Y, Hashimoto T, higashiyama M, Igarashi A, Ihn H, Iwatsuki K, Kabashima K, Kawada A, Kawashima M, Nakamura K, Okubo Y, Okuyama R, Ozawa A, Sayama K, Seishima M, Shiohara T, Takahara M, Takahashi H, Takehara K, Tanase K, Tani M, Umezawa Y, Watanabe H, Yamanaka K.
Efficacy and safety of ixekizumab treatment for Japanese patients with moderate to severe plaque psoriasis, erythrodermic psoriasis and generalized pustular psoriasis: Results from a 52-week, open-label, phase 3 study (UNCOVER-J).
J Dermatol, 44(4): 355-62, 2017.
56) Tachibana T, Imafuku S, Irisawa R, Ohtsuka M, Kadono T, Fujiwara H,Asano Y,Abe M, Ishii T, Isei T, Ito T, Inoue Y, Ohtsuka M, Ogawa F, Kodera M, Kawakami T, Kawaguchi M, Kukino R, Kono T, Sakai K, Takahara M, Tanioka M, Nakanishi T, Nakamura Y, Hashimoto A, Hasegawa M, Hayashi M, Fujimoto M, Maekawa T, Matsuo K, Madokoro N, Yamasaki O, Yoshino Y, Andres LE PAVOUX, Ihn H.
The wound burn guidelines–2: Guidelines for the diagnosis and treatment for pressure ulcers.
J Dermatol, 43: 469–506, 2016.
57) Tsutsumida A, Takahashi A, Namikawa K, Yamazaki N, Uhara H, Teramoto Y, Takenouchi T, Fukushima S, Yokota K, Uehara J, Matsushita S, Shibayama Y, Hatta N, Masui Y, Uchi H, Fujisawa Y, Ogata D.
Frequency of level II and III axillary nodes metastases in patients with positive sentinel lymph nodes in melanoma: a multi-institutional study in Japan.
Int J Clin Oncol, 21(4): 796-800, 2016.
58) Terao C, Kawaguchi T, Dieude P, Varga J, Kuwana M, Hudson M, Kawaguchi Y, Matucci M, Ohmura K, Riemekasten G, Kawasaki A, Airo P, Horita T, Oka A, Hachulla E, Yoshifuji H, Japanese Scleroderma Genetic Consortium, Caramaschi P, Hunzelman N, Baron M, Hassouns P, Raychaudhuri S, Liao K, Gregersen P, Torii T, Tsuchiya N, Takehara K, Sato S, Ihn H, Riccieri V, Melchers I, Valentini G, Cauvet A, Martinez M, Mimori T, Matsuda F, Allanore Y.
Trans-ethnic meta-analysis of genome-wide association study identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis.
Ann Rheum Dis, 76(6): 1150-8, 2017.
59) Torii H, Nakano M, Yano T, Kadono K, Nakagawa H, Fujita Y, Horie K, Ito M, Iitani M, Ito K, Kaneko T, Akasaka T, Ohtsuki M, Yasuda M, Abe M, Tanida Y, Terui T, Arai S, Nakano T, Etoh T, Asano Y, Umezawa Y, Saeki H, Adachi M, Seishima M, Tokura Y, Morita A, Yamanaka K, Tani M, Tanimura H, Yamazaki F, Nishigori C, Kaneko S, Muto M, Nakamura M, Hino R, Nakayama J, Nakano T, Utani A, Sato T, Ihn H.
Efficacy and safety of dose escalation of infliximab therapy in Japanese patients with psoriasis: Results of the SPREAD study.
J Dermatol, 44(5): 552-9, 2017.
60) Niimori-Kita K, Nakamura F, Niimori D.
Nuclear phosphoproteomics features the novel smoking markers in mouse lung tissue following subacute phase exposure to tobacco smoke.
J Bioanal Biomed 8(1): 9-16, 2016.
61) Hamaguchi Y, Sumida T, Kawaguchi Y, Ihn H, Tanaka S, Asano Y, Motegi S, Kuwana M, Endo H, Takehara K.
Safety and tolerability of bosentan for digital ulcers in Japanese patients with systemic sclerosis: prospective, multicenter, open-label study.
J Dermatol, 44: 13-17, 2017.
62) Fujimoto M, Asano Y, Ishii T, Ogawa F, Kawakami T, Kodera M, Abe M, Isei T, Ito T, Inoue Y, Imafuku S, Irisawa R, Ohtsuka M, Ohtsuka M, Kadono T, Kawaguchi M, Kukino R, Kono T, Sakai K, Takahara M, Tanioka M, Nakanishi T, Nakamura Y, Hashimoto A, Hasegawa M, Hayashi M, Fujiwara H, Maekawa T, Matsuo K, Madokoro N, Yamasaki O, Yoshino Y, Le Pavoux A, Tachibana T, Ihn H.
The woud/ burn guidelines – 4: Guidelines for management of skin ulcers associated with connective tissue disease/ vasculitis.
J Dermatol, 43: 729-757, 2016.
63) Yamazaki N, Kiyohara Y, Uhara H, Uehara J, Fujimoto M, Takenouhi T, Otsuka M, Uchi H, Ihn H, Minami H.
Efficacy and safety of nivolumab in Japanese patients with previously untreated advanced melanoma: a phase II study.
Cancer Sci, 108(6): 1223-30, 2017.
64) Yamazaki N, Kiyohara Y, Uhara H, Iizuka H, Uehara J, Ohtsuka F, Fujisawa Y, Tekenouchi T, Isei T, Iwatsuki K, Uchi H, Ihn H, Minami H, Tahara H.
Cytokine biomarkers to predict antitumor responses to nivolumab suggested in a phase 2 study for advanced melanoma.
Cancer Science, 108(5): 1022-31, 2017.
65) Yamazaki N, Takenouchi N, Fujimoto M, Ihn H, Uchi H, Inozume T, Kiyohara Y, Uhara H, Nakagawa K, Furukawa H, Wada H, Noguchi K, Shimamoto T, Yokota K.
Phase 1b study of pembrolizumab (MK-3475; anti-PD-1 monoclonal antibody) in Japanese patients with advanced melanoma (KEYNOTE-041).
Cancer Chemother Pharmacol, 79(4), 651-60, 2017.
2017年論文目録
1) Ikeda I, Igata T, Ihn H.
First aid for skin tears by mini patch grafting from the flap edge.
J Emerg Med, 54(4): 514-515, 2018.
2) Ichihara A, Jinnin M, Ihn H.
Treatment of psoriasis with ustekinumab improved skin tightening in systemic sclerosis.
Clin Exp Rheumatol, 106(4): 208-210, 2017.
3) Aoi J, Fukushima S, Jinnin M, Ihn H.
Fluorescence in situ hybridization for diagnosis of malignant melanoma using RREB1, MyB, Cep6, and CCND1 probes in Japanese patients.
Dermatologica Sinica, 35(4): 213-214, 2017.
4) Aoi J, Kajihara I, Masuguchi S, Fukushima S, Ihn H.
A simple and effective modification of axial frontonasal flap to prevent flap distortion.
J Dermatol, in press.
5) Makino K, Makino T, Stawski L, Lipson KE, Leask A, Trojanowska M.
Anti-connective tissue growth factor (CTGF/CCN2) monoclonal antibody attenuates skin fibrosis in mice models of systemic sclerosis.
Arthritis Res Ther, 19(1): 134, 2017.
6) Makino K, Makino T, Stawski L, Mantero LC, Lafyatis R, Simms R, Trojanowska M.
Blockade of PDGF receptors by crenolanib has therapeutic effect in patient fibroblasts and in preclinical models of systemic sclerosis.
J Invest Dermatol, 137(8): 1671-1681, 2017.
7) Kajihara I, Yamada-Kanazawa S, Maeda-Otsuka S, Jinnin M, Akaike K, Ihn H.
Secukinumab-induced interstitial pneumonia in a patient with psoriasis vulgaris.
J Dermatol, 44(12): 322-323, 2017.
8) Nakahara S, Fukushima S, Yamashita J, Kubo Y, Tokuzumi A, Miyashita A, Harada M, Nakamura K, Jinnin M, Ihn H.
AT-rich interaction domain-containing protein 3B is a new tumour marker for melanoma.
Acta Derm Venereo, 97(1): 112-114, 2017.
9) Ishibashi T, Jinnin M, Kajihara I, Fukushima S, Ihn H.
Bullous dermatosis on legs of elderly: A new clinical entity?
Drug Discov Ther, 11(6): 346-348, 2017.
10) Inoue M, Miyashita A, Noguchi H, Hirose N, Nishimura K, Masuda M, Ihn H.
Case report of cutaneous protothecosis caused by Prototheca wickerhamii designated as genotype 2 and current status of human protothecosis in Japan.
J Dermatol, 45(1): 67-71, 2018.
11) Egashira S, Kajihara I, Kanemaru H, Uemura-Kiyohara M, Yamada-Kanazawa S, Nakahara S, Nagamoto E, Fukushima S, Jinnin M, Inoue Y, Ihn H.
Achieved good response of S-1 and docetaxel combination chemotherapy in two patients with metastatic extramammary Paget’s disease.
J Dermatol, 44(5): 103-104, 2017.
12) Egashira S, Jinnin M, Ajino M, Shimozono N, Okamoto S, Tasaki Y, Hirano A, Ide M, Kajihara I, Aoi J, Harada M, Igata T, Masuguchi S, Fukushima S, Ihn H.
Chronic sun exposure-related fusion oncogenes EGFR-PPARGC1A in cutaneous squamous cell carcinoma.
Sci Rep, 7: 12654, 2017.
13) Kanemaru H, Yamane F, Fukushima K, Matsuki T, Kawasaki T, Ebina I, Kuniyoshi K, Tanaka H, Maruyama K, Maeda K, Satoh T, Akira S.
Antitumor effect of Batf2 through IL-12 p40 up-regulation in tumor-associated macrophages.
Proc Natl Acad Sci U S A, 114(35): 7331-7340, 2017.
14) Sawamura S, Kajihara I, Jinnin M, Honda Y, Ihn H.
Cutaneous spindle cell adenolipoma on the nose: A rare variant of lipoma.
J Dermatol, 44(7): 156-157, 2017.
15) Sawamura S, Jinnin M, Shimbara M, Nakamura K, Kudo H, Inoue K, Nakayama W, Kajihara I, Fukushima S, Ihn H.
Serum levels of genomic DNA of α1(I) collagen are elevated in scleroderma patients.
J Dermatol, 44(8): 927-931, 2017.
16) Sawamura S, Jinnin M, Kajihara I, Makino K, Aoi J, Ichihara A, Makino T, Fukushima S, Ihn H.
Do scleroderma patients look young?: Evaluation by using facial imaging system.
Drug Discov Ther, 11(6): 342-345, 2017.
17) Sawamura S, Kajihara I, Makino K, Makino T, Fukushima S, Jinnin M, Oyama B, Hashimoto T, Ihn H.
Systemic lupus erythematosus associated with myasthenia gravis, pemphigus foliaceus and chronic thyroiditis after thymectomy.
Australas J Dermatol, 58(3): 120-122, 2017.
18) Sawamura S, Jinnin M, Inoue K, Yamane K, Honda N, Kajihara I, Makino T, Masuguchi S, Fukushima S, Ihn H.
Regulatory mechanisms of collagen expression by interleukin-22 signaling in scleroderma fibroblasts.
J Dermatol Sci, 90(1): 52-59, 2018.
19) Sawamura S, Makino T, Johno T, Yamashita J, Niimori D, Fukushima S, Ihn H.
Severe bacterial sepsis results in delayed diagnosis of tuberculous lymphadenitis in a rheumatoid arthritis patient treated with adalimumab.
Intractable Rare Dis Res, 7(2): 138-140, 2018.
20) Shimada S, Fukushima S, Niimori D, Miyashita A, Setoyama H, Sasaki Y, Ihn H.
Dabrafenib and trametinib combination therapy safely performed in a patient with metastatic melanoma after severe liver toxicity due to vemurafenib.
J Dermatol, 45(6): 157-158, 2018.
21) Sonoda-Shimada K, Kajihara I, Shimada S, Igata T, Jinnin M, Ihn H.
Case of pigmented lipofibromatosis in a 27-year-old woman.
J Dermatol, 45(5), 128-129, 2018.
22) Nakashima S, Jinnin M, Kanemaru H, Kajihara I, Igata T, Okamoto S, Tazaki Y, Harada M, Masuguchi S, Fukushima S, Masuzawa M, Amoh Y, Masuzawa M, Ihn H.
The role of miR-210, E2F3 and ephrin A3 in angiosarcoma cell proliferation.
Eur J Dermatol, 27(5): 464-471, 2017.
23) Nakayama W, Jinnin M, Tomizawa Y, Nakamura K, Kudo H, Inoue K, Makino K, Honda N, Kajihara I, Fukushima S, Ihn H.
Dysregulated interleukin-23 signalling contributes to the increased collagen production in scleroderma fibroblasts via balancing microRNA expression.
Rheumatology (Oxford), 56(1): 145-155, 2017.
24) Noda-Yamashita T, Kajihara I, Kidou M, Ihn H.
Dyskeratosis congenita associated with congenital hypothyroidism.
J Dermatol, 45(4): 76-77, 2018.
25) Maeda-Otsuka S, Kajihara I, Ogata A, Johno T, Jinnin M, Ihn H.
Bromoderma in a pituitary adenoma patient treated with bromocriptine.
J Dermatol, 44(5): 95-96, 2017.
26) Miyamura T, Kajihara I, Makino K, Ihn H.
Sweet’s syndrome with laryngoparalysis due to laryngitis.
J Dermatol, in press.
27) Yamada-Kanazawa S, Kajihara I, Fukushima S, Jinnin M, Masuzawa M, Masuzawa M, Amoh Y, Hoshina D, Abe R, Ihn H.
Inhibition of heat shock protein 90 exerts an antitumor effect in angiosarcoma: involvement of the vascular endothelial growth factor signaling pathway.
Br J Dermatol, 177(2): 456-469, 2017.
28) Jinnin M, Yamamoto T, Asano Y, Ishikawa O, Sato S, Takehara K, Hasegawa M, Fujimoto M, Ihn H.
Diagnostic criteria, severity classification and guidelines of eosinophilic fasciitis.
J Dermatol, 45(8): 881-890, 2018.
29) Noguchi H, Hiruma M, Matsumoto T, Kano R, Ihn H.
Ungual hyalohyphomycosis caused by Fusarium proliferatum in an immunocompetent patient.
J Dermatol, 44(1): 88-90, 2017.
30) Noguchi H, Hiruma M, Matsumoto T, Yaguchi T, Sano A, Mitsui N, Watanabe S, Ihn H.
Subcutaneous cystic phaeohyphomycosis due to Pleurostomophora richardiae.
J Dermatol, 44(4): 62-63, 2017.
31) Noguchi H, Hiruma M, Matsumoto T, Kano R, Tanaka M, Yaguchi T, Sonoda K, Ihn H.
Fungal melanonychia: Ungual phaeohyphomycosis caused by Botryospheria dothidea.
Acta Derm Venereol, 97(6): 765-766, 2017.
32) Noguchi H, Hiruma M, Matsumoto T, Yaguchi T, Tashima H, Ihn H.
Multiple subcutaneous Candida abscesses on the palm and finger in an immunocompetent patient.
J Dermatol, 44(7): 174-177.
33) Noguchi H, Hiruma M, Matsumoto T, Kano R, Ihn H.
Ungual aspergillosis successfully treated with topical efinaconazole.
J Dermatol, 44(7): 848-850, 2017.
34) Noguchi H, Hiruma M, Matsumoto T, Asao K, Hirose M, Fukushima S, Ihn H.
Topical efinazonazole: As a therapeutic medication of severe tinea unguium.
J Dermatol, in press.
35) Ide M, Jinnin M, Tomizawa Y, Wang Z, Kajihara I, Fukushima S, Hashizume Y, Asano Y, Ihn H.
Transforming growth factor β-inhibitor Repsox downregulates collagen expression of scleroderma dermal fibroblasts and prevents bleomycin-induced mice skin fibrosis.
Exp Dermatol, 26(11): 1139-1143, 2017.
36) Kanamori S, Kajihara I, Yamada-Kanazawa S, Maeda-Otsuka S, Ihn H.
Expression of aurora kinase A expression in dermatofibrosarcoma protuberans.
J Dermatol, 45(4): 507-508, 2018.
37) Wang Z, Jinnin M, Harada M, Kudo H, Inoue K, Nakayama W, Honda N, Makino K, Kajihara I, Fukushima S, Ihn H.
Diagnosis of nail psoriasis: evaluation of nail-derived microRNAs as potential novel biomarkers.
Eur J Dermatol, 27(1): 20-27, 2017.
38) Asano Y, Jinnin M, Kawaguchi Y, Kuwana M, Goto D, Sato S, Takehara K, Hatano M, Fujimoto M, Mugii N, Ihn H.
Diagnostic criteria, severity classification and guidelines of systemic sclerosis.
J Dermatol, 45(6): 633-691, 2018.
39) Asano Y, Fujimoto M, Ishikawa O, Sato S, Jinnin M, Takehara K, Hasegawa M, Yamamoto T, Ihn H.
Diagnostic criteria, severity classification and guidelines of localized scleroderma.
J Dermatol, 45(7): 755-780, 2018.
40) Abe M, Nishigori C, Torii H, Ihn H, Ito K, Nagaoka M, Isogawa N, Kawaguchi I, Tomochika Y, Kobayashi M, Tallman AM, Papp KA.
Tofacitinib for the treatment of moderate to severe chronic plaque psoriasis in Japanese patients: Subgroup analyses from a randomized, placebo-controlled phase 3 trial.
J Dermatol, 44(11): 1228−1237, 2017.
41) Amagai M, Ikeda S, Hashimoto T, Mizuashi M, Fujisawa A, Ihn H, Matsuzaki Y, Ohtsuka M, Fujiwara H, Furuta J, Tago O, Yamagami J, Tanikawa A, Uhara H, Morita A, Nakanishi G, Tani M, Aoyama Y, Makino E, Muto M, Manabe M, Konno T, Murata S, Izaki S, Watanabe H, Yamaguchi Y, Matsukura S, Seishima M, Habe K, Yoshida Y, Kaneko S, Shindo H, Nakajima K, Kanekura T, Takahashi K, Kitajima Y, Hashimoto K.
A randomized double-blind trial of intranenous immunoglobulin for bullous pemphigoid.
J Dermatol Sci, 85(2): 77-84, 2017.
42) Arima H, Motoyama K, Higashi T, Fukushima S, Ihn H.
Anti-inflammatory effect of sacran on atopic dermatitis.
Yakugaku Zasshi, 138(4): 509-515, 2018.
43) Weber J, Mandala M, Del Vecchio M, Ggas HJ, Arance AM, Cowey CL, Dalle S, Svhenker M, Chiarion-Sileni V, Marquez-Rodas I, Grob JJ, Butler MO, Middleton MR, Maio M, Atkinson V, Queirolo P, Gonzalez R, Kudchadkar RR, Smylie M, Meyer N, Mortier L, Atkins MB, Long GV, Bhatia S, LeBBe C, Rutkowski P, Yokota K, Yamazaki N, Kin TM, de Prol V, Sabater J, Qureshi A, Larkin J, Ascerto PA, Cinat G, Zarba J, Brown M, Carlino M, Cebon J, Haydon A, Hersey P, Hill A, McNeil C, Millward M, Laimer M, Richtig E, Bauriain JF, Beuselinck B, Kruse V, Neyns B, Claveau J, Miller W, Savage K, Arenberger P, Krajsova I, Kubala E, Vantuchova Y, Hernberg M, Skyttä T, Dreno B, Bafaloukos D, Liszkay G, Donnellan P, Gullo G, McCaffrey J, Cognetti F, Guidoboni M, Queirolo P, Fujimoto M, Ihn H, Inozume T, Koga H, Ozawa K, Takenouchi T, Uchi H, Yoshikawa S, Lee DH, Lee J, Shin SJ, Hospers G, Koornstra R, Van Den Eertwegh A, Vreugdenhil G, Nyakas M, Straume O, Pikiel J, Ziobro M, Ciuleanu T, Cohen G, Jacobs C, McAdam G, Rapoport BL, Vorobiof D, Berrocal A, De La Cruz L, Carneiro A, Ny L, Dummer R, Chen YY, Lin CY, Faust G, Herbert C, Lorigan P, Nathan P, Ottensmeier C, Plummer R, Wagstaff J, Agarwala S, Amatruda T, Amin A, Curti B, Daniels G, Daud A, Fecher L, Gaughan E, Hamid O, Hernandez Aya L, Hutchins L, Infante J, Kendra K, Khushalani N, Kim K, Luke J, Lutzky J, Nair S, Ott PA, Pavlick A, Pecora A, Reuben D, Salama A, Shoushtari A, Silk A, Taylor M, Thomas S, Zaiden R.
Ajuvant nivolumab versus ipillimumab in resected stage III or IV melanoma.
N Eng J Med, 377: 1824-1835, 2017.
44) Oka A, Asano Y, Hasegawa M, Fujimoto M, Ishikawa O, Kuwana M, Kawaguchi Y, Yamamoto T, Takahashi H, Goto D, Endo H, Jinnin M, Mano S, Hosomichi K, Mabuchi T, Ueda MT, Nakagawa S, Beck S, Bahram S, Takehara K, Sato S, Ihn H.
RXRB is an MHC-encoded susceptibility gene associated with anti-topoisomerase I antibody-positive systemic sclerosis.
J Invest Dermatol, 137(9): 1878-1886, 2017.
45) Ogata-Aoki H, Higashi-Kuwata N, Hattori SI, Hayshi H, Danish M, Aoki M, Shiotsu C, Hashiguchi Y, Hamada A, Kobayashi H, Ihn H, Okada S, Mitsuya H.
Raltegravir blocks the infectivity of red-fluorescent-protein (mCherry)-labeled HIV-1JR-FL in the setting of post-exposure prophylaxis in NOD/SCID/Jak3-/- mice transplanted with human PBMCs.
Antiviral Res, 149: 78-88, 2018.
46) Okiyama N, Asano Y, Hamaguchi Y, Jinnin M, Motegi S, Koizumi H, Hasegawa M, Ishikawa O, Sato S, Takehara K, Yamamoto T, Fujimoto M, Ihn H.
Impact of a new simplified disability scoring system for adult patients with localized scleroderma.
J Dermatol, 45(4): 431-435, 2018.
47) Kawase M, Egawa K, Ishiji T, Nakagawa H.
Human papillomavirus type 6/11 identified in an epidermoid cyst of the scrotum.
J Dermatol, 45(2): 224-227, 2018.
48) Grzegorzewska AP, Seta F, Han R, Czajka CA, Makino K, Stawski L, Isenberg JS, Browning JL, Trojanowska M.
Dimethyl Fumarate ameliorates pulmonary arterial hypertension and lung fibrosis by targeting multiple pathways.
Sci Rep, 7: 41605, 2017.
49) Saeki H, Nakagawa H, Nakajo K, Ishii T, Morisaki Y, Aoki T, Cameron GS, Osuntokun OO, Akasaka T, Asano Y, Etoh T, Fujita Y, Hashimoto T, higashiyama M, Igarashi A, Ihn H, Iwatsuki K, Kabashima K, Kawada A, Kawashima M, Nakamura K, Okubo Y, Okuyama R, Ozawa A, Sayama K, Seishima M, Shiohara T, Takahara M, Takahashi H, Takehara K, Tanase K, Tani M, Umezawa Y, watanabe H, Yamanaka K.
Efficacy and safety of ixekizumab treatment for Japanese patients with moderate to severe plaque psoriasis, erythrodermic psoriasis and generalized pustular psoriasis: Results from a 52-week, open-label, phase 3 study (UNCOVER-J).
J Dermatol, 44(4): 355-362, 2017.
50) Sato Y, Kajihara I, Yamada-Kanazawa S, Jinnin M, Ihn H.
S100A7 expression levels in coordination with interleukin-8 indicate the clinical response to infliximab for psoriasis patients.
J Dermatol, 44(7): 838-839, 2017.
51) Suzuki S, Ishikawa N, Konoeda F, Seki N, Fukushima S, Takahashi K, Uhara H, Hasegawa Y, Inomata S, Otani Y, Yokota K, Hirose T, Tanaka R, Suzuki N, Matsui M.
Nivolumab-related myasthenia gravis with myositis and myocarditis in Japan.
Neurology, 89(11): 1127-1134, 2017.
52) Tanoue Y, Sun J, Toyoda T, Tateishi C, Motoyama N, Araki K, Tsukamoto T, Takeya M, Ihn H, Tateishi S.
Chk2 knockout mice develop skin tumors following UV-B irradiation.
J Invest Dermatol, in press.
53) Tanoue Y, Toyoda T, Sun J, Tateishi C, Endo S, Motoyama N, Araki K, Wu D, Okuno Y, Tsukamoto T, Takeya M, Ihn H, Vaziri C, Tateishi S.
Differential roles of Rad18 and ChK2 in genome maintenance and skin carcinogenesis following UV exposure.
J Invest Dermatol, in press.
54) Tsukamoto H, Fujieda K, Miyashita A, Fukushima S, Ikeda T, Kubo Y, Senju S, Ihn H, Nishimura Y, Oshiumi H.
Combined blockade of IL-6 and PD-1/PD-L1 signals breaks mutual regulation of their immunosuppressive effects in tumor microenvironment.
Cancer Res, in press.
55) Terao C, Kawaguchi T, Dieude P, Varga J, Kuwana M, Hudson M, Kawaguchi Y, Matucci M, Ohmura K, Riemekasten G, Kawasaki A, Airo P, Horita T, Oka A, Hachulla E, Yoshifuji H, Japanese Scleroderma Genetic Consortium, Caramaschi P, Hunzelman N, Baron M, Hassouns P, Raychaudhuri S, Liao K, Gregersen P, Torii T, Tsuchiya N, Takehara K, Sato S, Ihn H, Riccieri V, Melchers I, Valentini G, Cauvet A, Martinez M, Mimori T, Matsuda F, Allanore Y.
Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis.
Ann Rheum Dis, 76(6): 1150-1158, 2017.
56) Torii H, Nakano M, Yano T, Kadono K, Nakagawa H, Fujita Y, Horie K, Ito M, Iitani M, Ito K, Kaneko T, Akasaka T, Ohtsuki M, Yasuda M, Abe M, Tanida Y, Terui T, Arai S, Nakano T, Etoh T, Asano Y, Umezawa Y, Saeki H, Adachi M, Seishima M, Tokura Y, Morita A, Yamanaka K, Tani M, Tanimura H, Yamazaki F, Nishigori C, Kaneko S, Muto M, Nakamura M, Hino R, Nakayama J, Nakano T, Utani A, Sato T, Ihn H.
Efficacy and safety of dose escalation of infliximab therapy in Japanese patients with psoriasis: Results of the SPREAD study.
J Dermatol, 44(5): 552-559, 2017.
57) Nakamura Y, Kajihara I, Yamada-Kanazawa S, Maeda-Otsuka S, Johno T, Igata T, Masuguchi S, Fukushima S, Jinnin M, Ihn H.
Intratumor dihydropyrimidine dehydrogenase mRNA expression levels are decreased in extramammary Paget’s disease.
Drug Discov Ther, 11(3): 152-155, 2017.
58) Namikawa K, Tsutsumida A, Mizutani T, Shibata T, Takenouchi T, Yoshikawa S, Kiyohara Y, Uchi H, Furue M, Ogata D, Tsuchida T, Yamazaki N, and on behalf of the Dermatologic Oncology Group of the Japan Clinical Oncology Group.
Randomized phase III trial of adjuvant therapy with locoregional interferon beta versus surgery alone in stage II/III cutaneous melanoma: Japan Clinical Oncology Group Study (JCOG1309, J-FERON).
Jpn J of Clin Oncol, 47(7): 664-667, 2017.
59) Teramoto Y, Yamamoto A, Aoki M, Matsushita S, Fukushima S, Ihn H, Uhara H, Kiniwa Y, Uehara J, Ishida-Yamamoto A, Yokota K, Akiyama M, Hatta N, Masui Y, Sato S, Shibayama Y, Imafuku S.
In addition to the authors in the title page, the following authors have been contributing the JCOG1309 study:
Jpn J of Clin Oncol, 2017, 1-4.
60) Hamaguchi Y, Sumida T, Kawaguchi Y, Ihn H, Tanaka S, Asano Y, Motegi S, Kuwana M, Endo H, Takehara K.
Safety and tolerability of bosentan for digital ulcers in Japanese patients with systemic sclerosis: prospective, multicenter, open-labele study.
J Dermatol, 44(1): 13-17, 2017.
61) Higashi-Kuwata N, Ogata-Aoki H, Hattori SI, Hayshi H, Danish M, Aoki M, Shiotsu C, Kuwamura T, Ihn H, Kobayashi H, Okada S, Mitsuya H.
Early phase dynamics of traceable mCherry fluorescent protein-carring HIV-1 infection in human peripheral blood mononuclear cells-transplanted NOD/SCID/Jak3-/- mice.
Antiviral Res, 144: 83-92, 2017.
62) Maruyama K, Takayama Y, Kondo T, Ishibashi K, Bikash Ranjan Sahoo, Kanemaru H, Kumagai Y, Mikaël M. Martino, Tanaka H, Ohno N, Iwakura Y, Takemura N, Tominaga M, Akira S.
Nociceptors Boost the Resolution of Fungal Osteoinflammation via the TRP Channel-CGRP-Jdp2 Axis.
Cell Rep, 19(13): 2730-2742, 2017.
63) Yamamoto Y, Makino T, Kudo H, Ihn H, Murakami Y, Matsufuji S, Fujiwara K, Shin M.
Expression and distribution patterns of spermine, spermidine, and putrescine in rat hair follicle.
Histochem Cell Biol, 149(2): 161-167, 2018.
64) Yamazaki N, Takenouchi N, Fujimoto M, Ihn H, Uchi H, Inozume T, Kiyohara Y, Uhara H, Nakagawa K, Furukawa H, Wada H, Noguchi K, Shimamoto T, Yokota K.
Phase 1b study of pembrolizumab (MK-3475; anti-PD-1 monoclonal antibody) in Japanese patients with advanced melanoma (KEYNOTE-041).
Cancer Chemother Pharmacol, 79(4): 651-660, 2017.
65) Yamazaki N, Kiyohara Y, Uhara H, Iizuka H, Uehara J, Otsuka F, Fujisawa Y, Takenouchi T, Isei T, Iwatsuki K, Uchi H, Ihn H, Minami H, Tahara H.
Cytokine biomarkers to predict antitumor responses to nivolumab suggested in a phase 2 study for advanced melanoma.
Cancer Sci, 108(5): 1022-1031, 2017.
66) Yamazaki N, Kiyohara Y, Uhara H, Uehara J, Fujimoto M, Takenouhi T, Otsuka M, Uchi H, Ihn H, Minami H.
Efficacy and safety of nivolumab in Japanese patients with previously untreated advanced melanoma: a phase II study.
Cancer Sci, 108(6): 1223-1230, 2017.
67) Luong VH, Chino T, Oyama N, Matsushita T, Sasaki Y, Ogura D, Niwa SI, Biswas T, Hamasaki A, Fujita M, Okamoto Y, Otsuka M, Ihn H, Hasegawa M.
Blockade of TGF-/Smad signaling by the novel small compound HHP-15 ameliorates experimental skin fibrosis.
Arthrithis Res Ther, 20(1): 46, 2018.
2018年論文目録
1) Ikeda I, Igata T, Ihn H.
First aid for skin tears by mini patch grafting from the flap edge.
J Emerg Med, 54: 514-515, 2018.
2) Aoi J, Kajihara I, Masuguchi S, Fukushima S, Ihn H.
Simple and effective modification of the axial frontonasal flap to prevent flap distortion.
J Dermatol. 2018 Jun 15. doi: 10.1111/1346-8138.14506.
3) Egashira S, Jinnin M, Makino K, Ajino M, Shimozono N, Okamoto S, Tasaki Y, Hirano A, Ide M, Kajihara I, Aoi J, Harada M, Igata T, Masuguchi S, Fukushima S, Ihn H.
Recurrent fusion gene ADCK4-NUMBL in cutaneous squamous cell carcinoma mediates cell proliferation.
J Invest Dermatol, 139(4):954-957, 2018.
4) Sawamura S, Jinnin M, Inoue K, Yamane K, Honda N, Kajihara I, Makino T, Masuguchi S, Fukushima S, Ihn H.
Regulatory mechanisms of collagen expression by interleukin-22 signaling in scleroderma fibroblasts.
J Dermatol Sci, 90: 52-59, 2018.
5) Sawamura S, Jinnin M, Kajihara I, Makino K, Aoi J, Ichihara A, Makino T, Fukushima S, Ihn H.
Do scleroderma patients look young?: Evaluation by using facial imaging system.
Drug Discov Ther 11: 342-345, 2018.
6) Sawamura S, Makino T, Johno T, Yamashita J, Niimori D, Fukushima S, Ihn H.
Severe bacterial sepsis results in delayed diagnosis of tuberculous lymphadenitis in a rheumatoid arthritis patient treated with adalimumab.
Intractable Rare Dis Res, 7: 138-140, 2018.
7) Sawamura S, Niimori D, Ihn H.
A case of leg cellulitis caused by multi-drug resident Streptococcus pseudoporcinus. Intractable Rare Dis Res, 7: 280-282, 2018.
8) Noda-Yamashita T, Kajihara I, Kidou M, Ihn H.
Dyskeratosis congenita associated with congenital hypothyroidism.
J Dermatol, 45: e76-e77, 2018.
9) Yamashita T, Jinnin M, Makino K, Kajihara I, Aoi J, Masuguchi S, Fukushima S, Ihn H.
Serum cytokine profiles are altered in patients with progressive infantile hemangioma.
BioScience Trends, 12: 438-441, 2018.
10) Miyamura T, Kajihara I, Makino K, Ihn H.
Sweet’s syndrome with laryngoparalysis due to laryngitis.
J Dermatol, 45: e295-e296, 2018.
11) Sonoda-Shimada K, Kajihara I, Shimada S, Igata T, Jinnin M, Honda Y, Ihn H.
Case of pigmented lipofibromatosis in a 27-year-old woman.
J Dermatol, 45: e128-e129, 2018.
12) Shimada S, Fukushima S, Niimori D, Miyashita A, Setoyama S, Sasaki Y, Ihn H
Dabrafenib and trametinib combination therapy safely performed in a patient with metastatic melanoma after severe liver toxicity due to vemurafenib.
J Dermatol.45(6):e157-e158, 2018.
13) Kanemaru H, Yamane F, Tanaka H, Maeda K, Satoh T, Akira S
BATF2 activates DUSP2 gene expression and up-regulates NF-κB activity via phospho-STAT3 dephosphorylation.
International Immunology, 30(6):255–265, 2018.
14) Jinnin M, Yamamoto T, Asano Y, Ishikawa O, Sato S, Takehara K, Hasegawa M, Fujimoto M, Ihn H.
Diagnostic criteria, severity classification and guidelines of eosinophilic faciitis.
J Dermatol, 45: 881-890, 2018.
15) Noguchi H, Matsumoto T, Hiruma M, Asao K, Hirose M, Fukushima S, Ihn H. Topical efinazonazole: A promising therapeutic medication for tinea unguium.
J Dermatol, 45: 1225-1228, 2018.
16) Hirose M, Noguchi H, Yaguchi T, Matsumoto T, Hiruma M, Fukushima S, Ihn H.
Onychomycosis caused by Aspergillus subramanianii.
J Dermatol, 45: 1362-1366, 2018.
17) Kanamori S, Kajihara I, Kanazawa-Yamada S, Otsuka-Maeda S, Ihn H.
Expression of aurora kinase A in dermatofibrosarcoma protuberans.
J Dermatol, 45: e507-e508, 2018.
18) Ogata-Aoki H, Higashi-Kuwata N, Hattori SI, Hayshi H, Danish M, Aoki M, Shiotsu C, Hashiguchi Y, Hamada A, Kobayashi H, Ihn H, Okada S, Mitsuya H.
Raltegravir blocks the infectivity of red-fluorescent-protein (mCherry)-labeled HIV-1 JR-FL in the setting of post-exposure prophylaxis in NOD/SCID/Jak3-/- mice transplanted with human PBMCs.
Antiviral Res, 149: 78-88, 2018.
19) Fujisawa Y, Funakoshi T, Nakamura Y, Ishii M, Asai J, Shimauchi T, Fujii K, Fujimoto M, Katoh N, Ihn H.
Nation-wide ssurvey of advanced non-melanoma skin cancers treated at dermatology department in Japan.
J Derrmatol Sci, 92: 230-236, 2018.
20) Yamamoto Y, Makino T, Kudo H, Ihn H, Murakami Y, Matsufuji S, Fujiwara K, Shin M.
Exprssion and distribution patterns of spermine, sperminidine, and putrescine in rat hair folicle.
Histochem Cell Biol, 149: 161-167, 2018.
21) Luong VH, Chino T, Oyama N, Matsushita T, Sasaki Y, Ogura D, Niwa SI, Biswas T, Hamasaki A, Fujita M, Okamoto Y, Otsuka M, Ihn H, Hasegawa M.
Blockade of TGF-B /Smad signaling by the novel small compound HHP-15 ameliorates experimental skin fibrosis.
Arthrithis Res Ther, 20: 46, 2018.
22) Okiyama N, Asano Y, Hamaguchi Y, Jinnin M, Motegi S, Koizumi H, Hasegawa M, Ishikawa O, Sato S, Takehara K, Yamamoto T, Fujimoto M, Ihn H.
Impact of a new simplified disability scoring system for adult patients with localized scleroderma.
J Dermatol, 45: 431-435, 2018.
23) Asano Y, Jinnin M, Kawaguchi Y, Kuwana M, Goto D, Sato S, Takehara K, Hatano M, Fujimoto M, Mugii N, Ihn H.
Diagnostic criteria, severity classification, and guidelines of systemic sclerosis.
J Dermatol, 45: 633-691, 2018.
24) Hasegawa M, Ishikawa O, Asano Y, Sato S, Jinnin M, Takehara K, Fujimoto M, Yamamoto T, Ihn H.
Diagnostic criteria, severity classification and guidelines of lichen sclerosus et atrophics.
J Dermatol, 45: 891-897, 2018.
25) Tsukamoto H, Fujieda K, Miyashita A, Fukushima S, Ikeda T, Kubo Y, Senju S, Ihn H, Nishimura Y, Oshiumi H.
Combined blockade of IL-6 and PD-1/PD-L1 signaling abrogates mutual regulation of their immunosuppressive effects in the tumor microenvironment.
Cancer Res, 178: 5011-5022, 2018.
26) Tanoue Y, Toyoda T, Sun J, Tateishi C, Endo S, Motoyama N, Araki K, Wu D, Okuno Y, Tsukamoto T, Takeya M, Ihn H, Vaziri C, Tateishi S.
Differential roles of Rad18 and ChK2 in genome maintenance and skin carcinogenesis following UV exposure.
J Invest Dermatol, 138: 2550-2557, 2018.
27) Takamatsu K, Nakane S, Suzuki S, Kosaka T, Fukushima S, Kimura T, Miyashita A, Mukaino A, Yamakawa S, Watanabe K, Jinnin M, Komohara Y, Ihn H, Ando Y.
Immune checkpoint inhibitors in the onset of myasthenia gravis with hyperCKemia.
Ann Clin Transl Neurol, 5: 1421-1427, 2018.
28) Maruyama K, Takayama Y, Sugisawa E, Yamanoi Y, Yokawa T, Kondo T, Ishibashi K, Bikash Ranjan Sahoo, Takemura N, Mori Y, Kanemaru H, Kumagai Y, Mikaël M. Martino, Yoshioka Y, Nishijo H, Tanaka H, Sasaki A, Ohno N, Iwakura Y, Moriyama Y, Nomura M, Akira S, Tominaga M.
The ATP transporter VNUT mediates induction of Dectin-1-triggered Candida Nociception.
iScience, 6:306-318, 2018.
29) Nakagawa K, Matsuki T, Zhao L, Kuniyoshi K, Tanaka H, Ebina I, Yoshida KJ, Nabeshima H, Fukushima K, Kanemaru H, Yamane F, Kawasaki T, Machida T, Naito H, Takakura N, Satoh T, Akira S.
Schlafen-8 is essential for lymphatic endothelial cell activation in experimental autoimmune encephalomyelitis.
Int. Immunol. 30(2):69-78, 2018.
2019年論文目録
1) Ihn H.
Eosinophilic faciitis: from pathophysiology to treatment.
Allergol Int. 68:437-439, 2019
2) Sakai K, Fukushima S, Mizuhashi S, Jinnin M, Makino T, Inoue Y, Ihn H.
The effect of topical immunotherapy with squaric acid dibutylester (SADBE) for alopecia areata in Japanese patients.
Allergol Int. 69(2):274-278, 2019
3) Aoi J, Kajihara I, Masuguchi S, Fukushima S, Ihn H.
Simple and effective modification of axial frontonasal flap to prevent flap distortion.
J Dermatol. 46:e46-e47, 2019
4) Makino K, Aoi J, Egashira S, Honda N, Kubo Y, Kawakami Y, Hayashi H,Mochizuki T.
Multiple Skin Abscesses Caused by Rhizopus sp. Infection after Candida albicans Infection in an Immunocompromised Patient.
Med Mycol J. 60(1):17-21, 2019
5) Kanemaru H, Honda N, Kubo Y, Nishihara H, Onuma T, Sakai K, Fukushima S, Inoue Y, Ihn H.
Case of cutaneous myoepithelioma managed with surgical resection without recurrence for 4 years.
J Dermatol. 46(6):e206-e208, 2019
6) Sawamura S, Kajihara I, Ihn H.
A case of scleroderma associated with interstitial neutrophilic granulomatous reaction.
Austra J Dermatol. 60(4):e338-e340, 2019
7) Egashira S, Jinnin M, Makino K, Ajino M, Shimozono N, Okamoto S, Tasaki Y, Hirano A, Ide M, Kijihara I, Aoi J, Harada M, Igata T, Masuguchi S, Fukushima S, Ihn H.
Recurrent fusion gene, ADCK4-NUMBL in cutaneous squamous cell carcinoma mrdiates cell proliferation.
J Invest Dermatol. 139:954-957, 2019
8) Kaneko A, Kajihara I, Miyashita A, Ihn H.
A case of overlap syndrome (scleroderma and polymyositis) associated wuth the development of sudden pain due to myocardial damage.
Drug Discov Ther. 13(5):297-298, 2019
9) Kawano Y, Makino K, Jinnin M, Sawamura S, Shimada S, Fukushima S, Ihn H.
Royal Jelly regulates proliferation of human dermal microvascular endothelial cells via the down-regulation of photoaging-related microRNA.
Drug Discov Ther. 13(5):268-273, 2019
10) Kawano Y, Egawa K, Egawa G, Noguchi H, Ihn H.
Spontaneous regression of genital warts at untreated sites following elecrocoagulation treatment for the lesions at the other sites.
J Dermatol. 47(2):e46-e47, 2019
11) Kubo Y, Fukushima S, Inamori Y, Tsuruta M, Egashira S, Yamada-Kanazawa S, Nakahara S, Tokuzumi A, Miyashita A, Aoi J, Kajihara I, Tomita Y, Wakamatsu K, Jinnin M, Ihn H.
Serum concentrations of HGF are correlated with response to anti-PD-1 antibody therapy in patients with metastatic melanoma.
J Dermatol Sci. 96:33-40, 2019
12) Kuriyama H, Kajihara I, Kanemaru H, Nishimura Y, Igata T, Masuguchi S, Imaoka Y, Makino K, Ihn H.
Brain abcess in an angiosarcoma patient during a disease-free interval.
Drug Discov Ther. 13:175-176, 2019
13) Nakashima S, Jinnin M, Ide M, Kajihara I, Igata T, Harada M, Masuguchi S, Fukushima S, Masuzawa M, Masuzawa M, Amoh Y, Ihn H.
A potential significance of circ 0024169 down regulation in angiosarcoma tissue.
BioSci Trends. 8:129-133, 2019
14) Maeda-Otsuka S, Kajihara I, Tasaki Y, Yamada-Kanazawa S, Sakamoto R, Sawamura S, Masuzawa M, Amoh Y, Hoshina D, Abe R, Komohara Y, Ihn H.
Hypoxia accelerates the progression of angiosarcoma through the regulation of angiosarcoma cells and tumor microenvironment.
J Dermatol Sci. 93(2):123-132, 2019
15) Mizukami Y, Kanemaru H, Nakamura K, Hashigo S, Kajihara I, Miyashita A, Aoi J, Fukushima S, Honda Y, Ihn H.
Successful treatment of occult pancreastic melanoma using BRAF/MEK inhibitors.
J Dermatol. 47(4):e126-e127, 2019
16) Miyashita A, Fukushima S, Tsukamoto H, Itai H, Miyamoto H, Nakahara S, Kubo Y, Kimura T, Kuriyama H, Ihn H.
Nivolumab-induced colitis in a patient with malignant melanoma: A case report and immunological analysis.
J Dermatol 46(9):e339-e341, 2019
17) Miyashita K, Matsuo A, Johno M, Noguchi H, Matsumoto T, Hiruma M, Kimura U, Kano R, Yaguchi T, Ihn H.
Subcutaneous cystic phaeohyphomycosis caused by Exophiala jeanselmei.
J Dermatol. 46(12):e449-e451, 2019
18) Miyamura T, Egashira S, Yoshino Y, Sawatari M, Nishihara T, Ihn H.
Papulonecrotic tuberculid after Bacillus Calmette-Guerin (BCG) vaccination with lung infiltration that mimics disseminated BCG infection.
J Dermatol. 46:e267-e268, 2019
19) Yamada-Kanazawa S, Kajihara I, Kobayashi A, Watanabe C, Ihn H.
Infliximab improved the refractory cutaneous involvement in a patient with dermatomyositis.
Dermatol Ther. 12:e12859, 2019
20) Yamada-Kanazawa S, Tasaki Y, Kajihara I, Sakamo R, Maeda-Otsuka S, Ihn H.
The expression of EpCAM in extramanmmary Paget’s disease.
Intractable Rare Dis Res. 8:20-23, 2019
21) Noguchi H, Matsumoto T, Hiruma M, Kusuhara M, Ihn H.
Cutaneous cryptococcosis.
Medical Mycol J. 60(4):101-107, 2019
22) Noguchi H, Matsumoto T, Hiruma M, Kimura U, Kano R, Yaguchi T, Fukushima S, Ihn H.
Tinea unguium caused by terbinafine-resistant Trichophyton ruburum successfully treated with fosravuconazole.
J Dermatol. 46(12):e446-e447, 2019
23) Noguchi H, Matsumoto T, Kumura U, Hiruma M, Kano R, Yaguchi T, Fukushima S, Ihn H.
Fungual melanonychia caused by Candida parapsilisis successfully treated with oral fosravuconazole.
J Dermatol. 46:911-913, 2019
24) Noguchi H, Matsumoto T, Hiruma M, Kimura U, Yaguchi T, Hirose M, Fukushima S, Ihn H.
Interdigital hyalohyphomycosis caused by members of the Fusarium solani species complex.
Acta Derm. Venereol. 99:835-836, 2019
25) Hirose M, Noguchi H, Matsumoto T, Kimura U, Hiruma M, Kano R, Yaguchi T, Fujimoto N, Satoh T, Ihn H.
Ungual hyalohyphomycosis caused by a member of the Fusarium oxysporum Species Complex.
Acta Derm. Venereol. 99(9), 2019
26) Urata K, Kajihara I, Miyauchi H, Mijiddorj T, Otsuka-Maeda S, Sakamoto R, Sawamura S, Kanemaru H, Kanazawa-Yamada S, Makino K, Aoi J, Makino T, Fukusima S, Komohara Y, Ihn H.
The Warburg effect and tumor immune microenvironment in extramammary Paget’s disease: overexpression of LDHA correlates with immune resistance.
J Eur Acad Dermatol. in press.
27) Urata K, Kajihara I, Myangat TM, Tasaki Y, Otsuka-Maeda S, Sawamura S, Kanazawa-Yamada S, Sakamoto R, Makino K, Aoi J, Igata T, Makino T, Masuguchi S, Fukushima S, Jinnin M, Ihn H.
Overexpression of cyclin-dependent kinase 4 protein in extramammary Paget’s disease.
J Dermatol. 45:444-448, 2019
28) Mijiddorj T, Kajihara I, Tasaki Y, Otsuka-Maeda S, Sakamoto R, Sawamura S, Yamada-Kanazawa S, Egashira S, Inoue K, Makino K, Miyashita A, Aoi J, Igata T, Makino T, Masuguchi S, Fukushima S, Jinnin M, Morinaga J, Ikeda T, Ihn H.
Serum cell-free DNA levels are a useful marker for extramammary Paget’s disease.
Br J Dermatol. 181(3):505-511, 2019
29) Okamura K, Fukushima S, Yamashita J, Abe Y, Hayashi M, Hozumi Y, Ihn H, Suzuki T.
Natural course of epidermolysis bullaosa simplex with mottled pigmentation in a Japanese family with p.P25L mutation in KRT5.
J Dermatol. 46(7):e233-e235, 2019
30) Kawabata K, Makino T, Makino K, Kajihara I, Fukushima S, Ihn H.
IL-16 expression is increased in the skin and sera of patients with systemic sclerosis.
Rheumatology 59(3):519-523, 2019
31) Sueta D, Tabata N, Ikeda S, Saito Y, Ozaki K, Sakata K, Matsumura T, Yamamoto-Ibusyku M, Murakami Y, Jodai T, Fukushima S, Yoshida N, Kamba T, Araki E, Iwase H, Fujii K, Ihn H, Kobayashi Y, Minamino T, Yamagishi M, Maemura K, baba H, Matsui K, Tsujita K.
Differential predictive factors in patients with or without cancer history. Experience frm multi-center surveillance.
Medicine 98(44):e17602, 2019
32) Tanaka K, Nakamura Y, Mizutani T, Shibata T, Tsutsumida A, Fukuda H, Matsushita S, Aoki M, Namikawa K, Ohe S, Fukushima S, Yamazaki N.
Dermatologic Oncology Group of the Japan Clinical Oncology Group. Confirmatory trial of non-amputative digit preservation surgery for subungual melanoma: Japan Clinical Oncology Group study (JCOG1602, J-NAIL study protocol).
BMC Cancer 19(1):1002, 2019
33) Tanita K, Fujimura T, Sato Y, Lyu C, Kambayashi Y, Ogata D, Fukushima S, Miyashita A, Nakajima H, Nakamura M, Morita A, Aiba S.
Bexarotene Reduces Production of CCL22 From Tumor-Associated Macrophages in Cutaneous T-Cell Lymphoma.
Front Oncol. 2019 Sep 20:9:907. doi: 10.3389/fonc.2019.00907. eCollection 2019
34) Tsuchiya N, Zhang R, Iwama T, Ueda N, Liu T, Tatsumi M, Sasaki Y, Shimoda R, Osako Y, Sawada Y, Kubo Y, Miyashita A, Fukushima S, Cheng Z, Nakai R, Takubo K, Okada S, Kaneko S, Ihn H, Kaisho T, Nishimura Y, Senju S, Endo I, Nakatsura T, Uemura Y.
Type I interferon delivery by iPSC-derived myeloid cells elicits antitumor immunity via XCR1+ dendritic cells.
Cell Rep. 29:162-175, 2019
35) Tsutsumida A, Fukushima S, Yokota K, Yoshikawa S, Yamasaki O, Tanemura A, Okuyama R, Uhara H, Muto Y, Miyashita A, Akiyama M, Kaji T, Koga H, Kato J, Katayama T, Itakura E, Yamazaki N, Kiyohara Y.
Japanese real-world study of sequential nivolumab and ipilimumab treatment in melanoma.
J Dermatol. 46(11):947-955, 2019
36) Fujisawa Y, Yoshikawa S, Minagawa A, Takenouchi T, Yokota K, Uchi H, Noma N, Nakamura Y, Asai J, Kato J, Fujiwara S, Fukushima S, Uehara J, Hoashi T, Kaji T, Fujimura T, Namikawa K, Yoshioka M, Murao N, Ogata D, Matsuyama K, Hatta N, Shibayama Y, Fujiyama T, Ishikawa M, Yamada D, Kishi A, Nakamura Y, Shimiauchi T, Fujii K, Fujimoto M, Ihn H, Katoh N.
Clinical and histopathological characteristics and servival analysis of 4594 Japanese patients with melanoma.
Cancer Med. 8:2146-2156, 2019
37) Fujisawa Y, Yoshikawa S, Miyagawa A, Takenouchi T, Yokota K, Uchi H, Noma N, Nakamura Y, Asai J, Kato J, Fujiwara S, Fukushima S, Uehara J, Hoashi T, Kaji T, Fujimura T, Namikawa K, Yoshioka M, Murata N, Ogata D, Matsuyama K, Hatta N, Shinbayama Y, Fujiyama T, Ishikawa M, Yamada D, Kishi A, Nakamura Y, Shimauchi T, Fujii K, Fujimoto M, Ihn H, Katoh N.
Classification of 3097 patients from the Japanese melanoma study database using the American Joint committee on cancer eighth edition cancer staging system.
J Dermatol Sci. 94:284-289, 2019
38) Morita A, Okuyama R, Katoh N, Tateishi C, Masuda K, Komori T, Ogawa E, Makino T, Nishida E, Nishimoto S, Muramoto K, Tsuruta D, Ihn H.
Efficacy and safety of adalimumab in Japanese patients with psoriatic arthritis and inadequate response to non-steroidal anti-inflammatory drugs (NSAIDs): a prospective, observational study.
Mod Rheumatol. 5:1-11, 2019
39) Yamazaki N, Kiyohara Y, Uhara H, Uehara J, Fujimoto M, Takenouchi T, Otsuka M, Ichi H, Ihn H, Hatsumichi M, Minami H.
Long-term follow up of nivolimab-treated Japanese patients with advanced or reccurent malignant melanoma who were previously untreated.
Cancer Sci. 110(6):1995-2003, 2019
40) Yamazaki N, Kiyohara Y, Uhara H, Uehara J, Fujisawa Y, Takenouchi T, Otsuka M, Uchi H, Ihn H, Hatsumichi M, Minami H.
Long-term follow up of nivolumab in previously untreated Japanese patients with advanced or recurrent malignant melanoma.
Cancer Sci. 110:1995-2003, 2019
41) Yokota K, Uchi H, Uhara H, Yoshikawa S, Takenouchi T, Inozume T, Ozawa K, Ihn H, Fujisawa Y, Qureshi A, Jiang J, Otsuka Y, Weber J, Yamazaki N.
Ajuvant therapy with nivolumab versus ipillimumab after complete resection of stage III/IV melanoma: Japanese subgroup analysis from the phase III CheckMate 238 study.
J Dermatol. 46(2):1197-1201, 2019
42) Yokoyama M, Egawa G, Makino T, Egawa K.
Erythroplasia of Queyrat treated with imiquimod 5% cream: The necessity of regimen guidelines.
Clin Case Rep. 7(4):723-725, 2019
2020年論文目録
1) Yoshino Y, Hashimoto A, Ikegami R, Irisawa R, Kanoh H, Sakurai E, Nakanishi T, Maekawa T, Tachibana T, Amano M, Hayashi M, Ishii T, Iwata Y, Kawakami T, Sarayama Y, Hasegawa M, Matsuo K, Ihn H, Omoto Y, Madokoro N, Isei T, Otsuka M, Kukino R, Shintani Y, Hirosaki K, Motegi S, Kawaguchi M, Asai J, Isogai Z, Kato H, Kono T, Tanioka M, Fujita H, Yatsushiro H, Sakai K, Asano Y, Ito T, Kadono T, Koga M, Tanizaki H, Fujimoto M, Yamasaki O, Doi N, Abe M, Inoue Y, Kaneko S, Kodera M, Tsujita J, Fujiwara H, Le Pavoux A.
Wound, pressure ulcer and burn guidelines – 6 : Guidelines for the management of burns, second edition.
J Dermatol. 47(11) : 1207-1235, 2020
2) Sakai K, Fukushima S, Mizuhashi S, Jinnin M, Makino T, Inoue Y, Ihn H.
Effect of topical immunotherapy with squaric acid dibutylester for alopecia areata in Japanese patients.
Allergol Int. 69 (2) : 274-278, 2020
3) Ishibashi T, Kajihara I, Mizuhashi S, Kuriyama H, Kimura T, Kanemaru H, Makino K, Miyashita A, Aoi J, Makino T, Fukushima S, Kita K, Ihn H.
Methyl-CpG binding domain protein 3: a new diagnostic marker and potential therapeutic target of melanoma.
BioSci Trends. 14(5) : 390-395, 2020
4) Otsuka-Maeda S, Kajihara I, Kanemaru H, Sawamura S, Makino K, Aoi J, Makino T, Fukushima S, Ihn H.
Retrospective study of COL1A1-PDGFB fusion gene-positive dermatofibrosarcoma protuberans in Kumamoto University.
Clin Exp Dermatol. 45(8) : 1067-1068, 2020
5) Oshikawa Y, Makino T, Nakayama M, Sawamura S, Makino K, Kajihara I, Aoi J, Masuguchi S, Fukushima S, Ihn H.
Increased CD27 expression in the skins and sera of patients with systemic sclerosis.
IRDR 9(2) : 99-103, 2020
6) Kanemaru H, Fukushima S, Mizukami Y, Sawamura S, Nakamura K, Honda N, Makino K, Kajihara I, Aoi J, Makino T, Kawasaki T, Kudou E, Johno M, Ito T, Arima N, Ihn H.
Single administration of avelumab induced a complete response in thyroid transcription factor-1 positive combined Merkel cell carcinoma.
J Dermatol. 47(11) : 1317-1321, 2020
7) Kawano Y, Egawa K, Egawa G, Egawa N, Honda Y, Noguchi H, Ihn H.
Spontaneous regression of genital warts at untreated sites following electrocoagulation treatment for lesions at the other sites.
J Dermatol. 47(2) : 46-47, 2020
8) Kimura T, Akamatsu Y, Kajihara I, Fukushima S, Ihn H.
Case of metastatic extramammary Paget's disease treated with trastuzumab-biosimilar monotherapy after S-1 and docetaxel combination chemotherapy.
J Dermatol. 47(1) : 1-2, 2020
9) Kimura T, Fukushima S, Okada E, Kuriyama H, Kanemaru H, Kadohisa-Tsuruta M, Kubo Y, Nakahara S, Tokuzumi A, Kajihara I, Makino K, Miyashita A, Aoi J, Makino T, Tsukamoto H, Nishimura Y, Inozume Y, Zhang R, Uemura Y, Senju S, Ihn H.
Induced pluripotent stem cell-derived myeloid cells expressing OX40 ligand amplify antigen-specific T cells in advanced melanoma.
Pigment Cell Melanoma Res. 33(5) : 744-755, 2020
10) Kiyohara S, Kanemaru H, Suzuki T, Nakamura K, Honda N, Makino K, Kajihara I, Makino T, Ohba T, Ihn H.
Successful prednisolone treatment of peripartum Behçet’s disease associated with HLA-A26.
Australasian Journal of Dermatology. 61(4) : 441-442, 2020
11) Kiyohara M, Aoi J, Kajihara I, Otuka S, Kadomatsu T, Fukushima S, Ihn H.
Serum anti-p53 autoantibodies in angiosarcoma.
J Dermatol. 47(8) : 849-854, 2020
12) Kuriyama H, Fukushima S, Nakahara S, Kanemaru H, Miyashita A, Aoi J, Tomita Y, Kawasaki T, Nosaka K, Ihn H.
Serious disseminated intravascular coagulation associated with combination therapy of nivolumab and ipilimumab in advanced melanoma.
J Dermatol. 47(6) : 235-237, 2020
13) Kuriyama H, Fukushima S, Kimura T, Okada E, Ishibashi T, Mizuhashi S, Kanemaru H, Kajihara I, Makino K, Miyashita A, Aoi J, Okada S, Ihn H, Kita K.
Matrin-3 plays an important role in cell cycle and apoptosis for survival in malignant melanoma.
J Dermatol Sci. 100(2) : 110-119, 2020
14) Sakamoto R, Sawamura S, Kajihara I, Miyauchi H, Urata K, Otsuka-Maeda S, Kanemaru H, Kanazawa-Yamada S, Honda N, Makino K, Miyashita A, Aoi J, Makino T, Fukushima S, Ihn H.
Circulating tumor necrosis factor-α DNA are elevated in psoriasis.
J Dermatol. 47(9) : 1037-1040, 2020
15) Sakamoto R, Kajihara I, Miyauchi H, Maeda-Otsuka S, Yamada-Kanazawa S, Sawamura S, Kanemaru H, Makino K, Aoi J, Makino T, Fukushima S, Masuzawa M, Masuzawa M, Amoh Y, Hoshina D, Abe R, Ihn H.
Inhibition of Endoglin Exerts Antitumor Effects through the Regulation of Non-Smad TGF-β Signaling in Angiosarcoma.
J Invest Dermatol. 140(10) : 2060-2072, 2020
16) Sawamura S, Kajihara I, Tasaki Y, Otsuka-Maeda S, Sakamoto R, Kanazawa-Yamada S, Makino K, Aoi J, Ihn H.
Overexpression of MUC16 (CA125) in extramammary Paget's disease.
Jpn J Clin Oncol. 50(11) : 1330-1332, 2020
17) Shimada S, Makino K, Jinnin M, Sawamura S, Kawano Y, Ide M, Kajihara I, Makino T, Fukushima S, Ihn H.
CXCL17-mediated downregulation of type I collagen via MMP1 and miR-29 in skin fibroblasts possibly contributes to the fibrosis in systemic sclerosis.
J Dermatol Sci. 100(3) : 183-191, 2020
18) Sonoda-Shimada K, Kajihara I, Jinnin M, Ihn H.
A successful case of lupus myelitis treated with intravenous pulse methylprednisolone and pulse cyclophosphamide therapy.
Drug Discov Ther. 14(4) : 209-210, 2020
19) Tanaka K, Myangat TM, Sawamura S, Otsuka-Maeda S, Sakamoto R, Kanazawa-Yamada S, Kanemaru H, Makino K, Aoi J, Kajihara I, Ihn H.
Genomic mutational profiling of circulating tumour DNA in metastatic angiosarcoma.
J Eur Acad Dermatol Venereol. Epub Dec.10, 2020
20) Nakashima K, Saruwatari K, Sato R, Imamura K, Kajihara I, Fukushima S, Saito T, Ishizuka S, Tamanoi D, Jodai T, Hamada S, Tomita Y, Saeki S, Ichiyasu H, Oya N, Ihn H, Sakagami T.
Non-small-cell Lung Cancer with Severe Skin Manifestations Related to Radiation Recall Dermatitis after Atezolizumab Treatment.
Intern Med. 59(9) : 1199-1202, 2020
21) Nakahara S, Fukushima S, Okada E, Morinaga J, Kubo Y, Tokuzumi A, Matsumoto S, Tsuruta-Kadohisa M, Kimura T, Kuriyama H, Miyashita A, Kajihara I, Jinnin M, Ihn H.
MicroRNAs that predict the effectiveness of anti-PD-1 therapies in patients with advanced melanoma.
J Dermatol Sci. 97(1) : 77-79, 2020
22) Mizukami Y, Kanemaru H, Nakamura K, Hashigo S, Kajihara I, Miyashita A, Aoi J, Fukushima S, Honda Y, Ihn H.
Successful treatment of occult pancreatic melanoma using BRAF/MEK inhibitors.
J Dermatol. 47(4) : 126-127, 2020
23) Mizukami Y, Sugawara K, Tsuruta D.
Female pattern hair loss with acromegaly.
Clin Exp Dermatol. Epub Oct.14, 2020
24) Mizuhashi S, Kajihara I, Sawamura S, Kanemaru H, Makino K, Aoi J, Makino T, Masuguchi S, Fukushima S, Ihn H.
Skin microbiome in acral melanoma: Corynebacterium is associated with advanced melanoma.
J Dermatol. Epub Oct.5, 2020
25) Noguchi H, Matsumoto T, Kimura U, Hiruma M, Kano R, Yaguchi T, Fukushima S, Ihn H.
Onychomycosis caused by Trichosporon cacaoliposimilis.
J Dermatol. 47(5) : 193-195, 2020
26) Noguchi H, Matsumoto T, Kimura U, Hiruma M, Kano R, Yaguchi T, Fukushima S, Ihn H.
Ungual hyalohyphomycosis caused by Fusarium proliferatum successfully treated with fosravuconazole.
J Dermatol. 47(7) : 251-253, 2020
27) Noguchi H, Matsumoto T, Kimura U, Hiruma M, Kano R, Kubo M, Fukushima S, Ihn H.
Fosravuconazole to treat severe onychomycosis in the elderly.
J Dermatol. Epub Oct.25, 2020
28) Urata K, Kajihara I, Miyauchi H, Mijiddorj T, Otsuka-Maeda S, Sakamoto R, Sawamura S, Kanemaru H, Kanazawa-Yamada S, Makino K, Aoi J, Makino T, Fukushima S, Komohara Y, Ihn H.
The Warburg effect and tumour immune microenvironment in extramammary Paget's disease : overexpression of lactate dehydrogenase A correlates with immune resistance.
J Eur Acad Dermatol Venereol. 34(8) : 1715-1721, 2020
29) Kakitsuka Y, Sawamura S, Kajihara I, Kanemaru H, Honda N, Makino K, Aoi J, Makino T, Fukushima S, Ihn H.
Elevated circulating cell-free DNA levels in autoimmune bullous diseases.
J Dermatol. 47(9) : 345-346, 2020
30) Kawabata K, Makino T, Makino K, Kajihara I, Fukushima S, Ihn H.
IL-16 expression is increased in the skin and sera of patients with systemic sclerosis.
Rheumatology (Oxford) 59(3) : 519-523, 2020
31) Tagawa H, Kanemaru H, Kimura T, Kuriyama H, Sawamura S, Kajihara I, Miyashita A, Aoi J, Fukushima S, Ihn H.
BATF2 expression as a novel marker for invasive phenotype in malignant melanoma.
J Dermatol. 47(10) : 372-373, 2020.
32) Egawa G, Egawa K, Kabashima K.
Case of chickenpox in which varicella zoster virus genotype E was identified for the first time in Japan.
J Dermatol. 47(1) : 54-57, 2020
33) Oikawa D, Sato Y, Ohtake F, Komakura K, Hanada K, Sugawara K, Terawaki S, Mizukami Y, Phuong HT, Iio K, Obika S, Fukushi M, Irie T, Tsuruta D, Sakamoto S, Tanaka K, Saeki Y, Fukai S, Tokunaga F.
Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.
Commun Biol. 3(1) : 163, 2020
34) Kurahashi R, Motoshima T, Fukushima Y, Murakami Y, Yatsuda J, Yamaguchi T, Sugiyama Y, Fukushima S, Komohara Y, Suekane S, Kamba T.
Remarkable antitumor effect of nivolumab in a patient with metastatic renal cell carcinoma previously treated with a peptidebased vaccine.
IJU Case Reports 3(2) : 44-48, 2020
35) Nakamura Y, Asai J, Igaki H, Inozume T, Namikawa K, Hayashi A, Fukushima S, Fujimura T, Ito T, Imafuku K, Tanaka R, Teramoto Y, Minagawa A, Miyagawa T, Miyashita A, Wada M, Koga H, Sugaya M.
Japanese Dermatological Association Guidelines : Outlines of guidelines for cutaneous melanoma 2019.
J Dermatol. 47(2) : 89-103, 2020
36) Nakamura Y, Namikawa K, Yoshino K, Yoshikawa S, Uchi H, Goto K, Nakamura Y, Fukushima S, Kiniwa Y, Takenouchi T, Uhara H, Kawai T, Hatta N, Funakoshi T, Teramoto Y, Otsuka A, Doi H, Ogata D, Matsushita S, Isei T, Hayashi T, Shibayama Y, Yamazaki N.
Anti-PD1 checkpoint inhibitor therapy in acral melanoma: A multicentre study of 193 Japanese patients.
Ann Oncol. 31(9) : 1198-1206, 2020
37) Nguyen MT, Lin CH, Liu SM, Miyashita A, Ihn H, Lin H, Ng CH, Tsai JC, Chen MH, Tsai MS, Lin IY, Liu SC, Li LY, Fukushima S, Lu J, Ma N.
miR-524-5p reduces the progression of the BRAF inhibitor-resistant melanoma.
Neoplasia. 22(12) : 789-799, 2020
38) Hasegawa M, Inoue Y, Kaneko S, Kanoh H, Shintani Y, Tsujita J, Fujita H, Motegi S, Le Pavoux A, Asai J, Asano Y, Abe M, Amano M, Ikegami R, Ishii T, Isei T, Isogai Z, Ito T, Irisawa R, Iwata Y, Otsuka M, Omoto Y, Kato H, Kadono T, Kawakami T, Kawaguchi M, Kukino R, Kono T, Koga M, Kodera M, Sakai K, Sakurai E, Sarayama Y, Tanioka M, Tanizaki H, Doi N, Nakanishi T, Hashimoto A, Hayashi M, Hirosaki K, Fujimoto M, Fujiwara H, Maekawa T, Matsuo K, Madokoro N, Yatsushiro H, Yamasaki O, Yoshino Y, Tachibana T, Ihn H.
Wound, pressure ulcer and burn guidelines – 1: Guidelines for wounds in general, second edition.
J Dermatol. 47(8) : 807-833, 2020
39) Fujimura T, Tanita K, Sato Y, Lyu C, Kambayashi Y, Fujisawa Y, Uchi H, Yamamoto Y, Otsuka A, Yoshino K, Matsushita S, Funakoshi T, Fukushima S, Hata H, Hashimoto A, Aiba S.
Immune checkpoint inhibitor-induced vitiligo in advanced melanoma could be related to increased levels of CCL19.
Br J Dermatol. 182(5) : 1297-1300, 2020
40) Fujimoto M, Asai J, Asano Y, Ishii T, Iwata Y, Kawakami T, Kodera M, Abe M, Amano M, Ikegami R, Isei T, Isogai Z, Ito T, Inoue Y, Irisawa R, Ohtsuka M, Omoto Y, Kato H, Kadono T, Kaneko S, Kanoh H, Kawaguchi M, Kukino R, Kono T, Koga M, Sakai K, Sakurai E, Sarayama Y, Shintani Y, Tanioka M, Tanizaki H, Tsujita J, Doi N, Nakanishi T, Hashimoto A, Hasegawa M, Hayashi M, Hirosaki K, Fujita H, Fujiwara H, Maekawa T, Matsuo K, Madokoro N, Motegi S, Yatsushiro H, Yamasaki O, Yoshino Y, Le Pavoux A, Tachibana T, Ihn H.
Wound, pressure ulcer and burn guidelines – 4 : Guidelines for the management of connective tissue disease/vasculitis‐associated skin ulcers.
J Dermatol. 47(10) : 1071-1109, 2020
41) Fujiwara H, Isogai Z, Irisawa R, Otsuka M, Kadono T, Koga M, Hirosaki K, Asai J, Asano Y, Abe M, Amano M, Ikegami R, Ishii T, Isei T, Ito T, Inoue Y, Iwata Y, Omoto Y, Kato H, Kaneko S, Kanoh H, Kawakami T, Kawaguchi M, Kukino R, Kono T, Kodera M, Sakai K, Sakurai E, Sarayama Y, Shintani Y, Tanioka M, Tanizaki H, Tsujita J, Doi N, Nakanishi T, Hashimoto A, Hasegawa M, Hayashi M, Fujita H, Fujimoto M, Maekawa T, Matsuo K, Madokoro N, Motegi S, Yatsushiro H, Yamasaki O, Yoshino Y, Le Pavoux A, Tachibana T, Ihn H.
Wound, pressure ulcer and burn guidelines – 2 : Guidelines for the diagnosis and treatment of pressure ulcers, second edition.
J Dermatol. 47(9) : 929-978, 2020
42) Furuta Y, Miyamoto H, Naoe H, Shimoda M, Hinokuma Y, Miyamura T, Miyashita A, Fukushima S, Tanaka M, Sasaki Y.
Cytomegalovirus Enterocolitis in a Patient with Refractory Immune-Related Colitis.
Case Rep Gastroenterol. 14(1) : 103-109, 2020
43) Morita A, Okuyama R, Katoh N, Tateishi C, Masuda K, Komori T, Ogawa E, Makino T, Nishida E, Nishimoto S, Muramoto K, Tsuruta D, Ihn H.
Efficacy and safety of adalimumab in Japanese patients with psoriatic arthritis and inadequate response to non-steroidal anti-inflammatory drugs (NSAIDs): A prospective, observational study.
Mod Rheumatol. 30(1) : 155-165, 2020
44) Yamamoto T, Ito T, Asano Y, Sato S, Motegi SI, Ishikawa O, Matsushita T, Takehara K, Makino T, Okiyama N, Fujimoto M, Jinnin M, Ihn H.
Characteristics of Japanese patients with eosinophilic fasciitis: A brief multicenter study.
J Dermatol. 47(12) : 1391-1394, 2020
45) Yokomichi H, Inozume T, Wada M, Asai J, Igaki H, Namikawa K, Hayashi A, Fukushima S, Fujimura T, Koga H, Nakamura Y, Mochizuki M, Yamagata Z.
Concordance and Discordance Rates of V-Raf Murine Sarcoma Viral Oncogene Homolog B1 (BRAF)V600E Status in Metastatic against Primary Lesion of Melanoma: A Meta-analysis.
JMA J. 3(3) : 274-279, 2020
46) Wakamatsu K, Fukushima S, Minagawa A, Omodaka T, Hida T, Hatta N, Takata M, Uhara H, Okuyama R, Ihn H.
Significance of 5-S-Cysteinyldopa as a Marker for Melanoma.
Int J Mol Sci. 21(2) : 432, 2020
熊本大学大学院生命科学研究部
皮膚病態治療再建学講座
Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University
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